Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

Table 3 Multivariate analysis of specific IgG, IgG1 and IgG3 antibody response levels in children

Ab response	Covariate factors	Total population		Petessou		Dar-es-Salam
Ab response	Covariate factors	Estimate	p	Estimate	p	Estimate	p
IgG anti-PfMSP1	Constant	1.240		1.488		0.172
	Age	0.018	0.58	0.069	0.715	− 0.005	0.871
	Group of exposure (ref = low exposure)	− 0.443	0.043	− 1.02	0.003	0.268	0.232
	Site (ref = Petessou)	− 0.823	< 0.001
IgG1 anti-PfMSP1	Constant	1.230		1.623		0.245
	Age	0.006	0.883	− 0.004	0.943	− 0.012	0.753
	Group of exposure (ref = low exposure)	− 0.397	0.107	− 1.09	0.006	0.386	0.148
	Site (ref = Petessou)	− 0.66	0.008	–	–	–	–
IgG3 anti-PfMSP1	Constant	0.951		0.881		0.081
	Age	0.057	0.066	0.081	0.154	0.027	0.363
	Group of exposure (ref = low exposure)	− 0.422	0.033	− 0.653	0.047	− 0.126	0.496
	Site (ref = Petessou)	− 0.895	< 0.0001	–	–	–	–

Ab response	Covariate factors	Total population		Petessou		Dar-es-Salam
Ab response	Covariate factors	Estimate	p	Estimate	p	Estimate	p
IgG anti-PfAMA1	Constant	− 0.025		1.64		0.129
	Age	0.018	0.562	0.044	0.416	− 0.007	0.813
	Group of exposure (ref = low exposure)	0.196	0.324	0.222	0.506	0.211	0.311
	Site (ref = Petessou)	− 1.871	< 0.0001	–	–	–	–
IgG1 anti-PfAMA1	Constant	0.028		2.37		0.216
	Age	0.006	0.87	0.029	0.683	− 0.008	0.813
	Group of exposure (ref = low exposure)	0.379	0.125	0.557	0.201	0.216	0.366
	Site (ref = Petessou)	− 2.576	< 0.0001	–	–	–	–
IgG3 anti-PfAMA1	Constant	0.021		1.42		0.045
	Age	0.046	0.167	0.069	0.262	0.014	0.548
	Group of exposure (ref = low exposure)	− 0.279	0.198	− 0.525	0.174	0.053	0.724
	Site (ref = Petessou)	− 1.462	< 0.0001	–	–	–	–

ISSN: 1475-2875