Exon number | 2 | 2 | 2 | 4 | 6 | 9 | 11 |
---|

Amino acid loci and substitution | 74 | 75 | 76 | 220 | 271 | 326 | 371 |
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Study sites | *N (nR)* | M/I (%) | N/E (%) | K/T (%) | A/S (%) | Q/E (%) | N/S (%) | R/I (%) |
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A. Kolasib | 29 | M (62.1) | N (62.1) | K (62.1) | A (86.2) | Q (86.2) | N (62.1) | R (86.2) |

(11) | I (37.9) | E (37.9) | T (37.9) | S (13.8) | E (13.8) | S (37.9) | I (13.8) |

B Mamit | 35 | M (40.0) | N (40.0) | K (40.0) | A (62.9) | Q (62.9) | N (40.0) | R (62.9) |

(21) | I (60.0) | E (60.0) | T (60.0) | S (37.1) | E (37.1) | S (60.0) | I (37.1) |

C. Aizawl | 36 | M (75.0) | N (75.0) | K (75.0) | A (100) | Q (100) | N (75.0) | R (100) |

(9) | I (25.0) | E (25.0) | T (25.0) | S (25.0) |

E. Serchhip | 21 | M (47.6) | N (47.6) | K (47.6) | A (100) | Q (100) | N (47.6) | R (100) |

(11) | I (52.4) | E (52.4) | T (52.4) | S (52.4) |

F. Lunglei | 61 | M (21.3) | N (21.3) | K (21.3) | A (52.5) | Q (52.5) | S (78.7) | R (52.5) |

(48) | I (78.7) | E (78.7) | T (78.7) | S (47.5) | E (47.5) | N (21.3) | I (47.5) |

G. Lawngtlai | 57 | M (21.1) | N (21.1) | K (21.1) | A (47.4) | Q (47.4) | N (21.1) | R (47.4) |

(45) | I (78.9) | E (78.9) | T (78.9) | S (52.6) | E (52.6) | S (78.9) | I (52.6) |

H. Saiha | 26 | M (61.5) | N (61.5) | K (61.5) | A (84.6) | Q (84.6) | N (61.5) | R (84.6) |

(10) | I (38.5) | E (38.5) | T (38.5) | S (15.4) | E (15.4) | S (38.5) | I (15.4) |

3D7 Reference sequence | M | N | K | A | Q | N | R |

Genotypes |

1. WT | M | N | K | A | Q | N | R |

2. R1 | I | E | T | A | Q | S | R |

3. R2 | I | E | T | S^{a} | E^{a} | S | I^{a} |

*n* total number of samples, *nR* number of samples with R forms, *WT* wild type, *R1* CQR type-1, *R2* CQR type-2^{a}Denotes additional substitutions; All calculations are in percentage