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Fig. 3 | Malaria Journal

Fig. 3

From: Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

Fig. 3

Global and temporal changes in metabolite abundance during the IDC. a Temporal fold-change values in significantly altered metabolites. Here, any metabolite that changed (i.e., increased or decreased) twofold or more in abundance was considered as significantly altered. The time-specific fold change was computed as \( {\text{m}}_{\text{iRBC}} / {\text{m}}_{\text{uRBC}} \), where m represents the metabolite abundance at 0, 8, 16, 24, 32, or 40 h, and uRBC and iRBC denote uRBC and iRBC cultures, respectively. Fold-change values greater than or equal to two are shown in black, and those smaller than two are shown in grey. b The number of metabolites in a that changed by twofold or more at the indicated time points. The number increased monotonically with time, suggesting that pronounced metabolic changes occur during the later stages of the IDC. c Fold change in the average abundance of metabolites from Clusters 15 in Fig. 2e. The fold change in average abundance (FCIDC) was computed as \( {\bar{\text{m}}}_{\text{iRBC}} / {\bar{\text{m}}}_{\text{uRBC}} \), where \( {\bar{\text{m}}} \) represents the average abundance of a metabolite ‘m’ averaged across all time points. Twofold changes in average abundance are shown in red (Cluster 1), magenta (Cluster 2), green (Cluster 4), or cyan (Cluster 5). Fold changes of less than two are shown in grey. Although Cluster 3 showed some temporal changes in metabolites (Fig. 2e), these disappeared when the FCIDC was computed (hence, all markers are grey). IDC intraerythrocytic developmental cycle, iRBC parasite-infected erythrocyte, uRBC uninfected erythrocyte

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