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Table 2 Fold changes in metabolite levels between infected and uninfected erythrocyte cultures

From: Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

MetaboliteFCIDC (SD)aPathwayMass (amu)bClusterc
15 metabolites showing the greatest increase
Pipecolate63.9 (10.1)Lysine degradation130.15
Nicotinic acid mononucleotide33.6 (3.19)Nicotinate and nicotinamide metabolism336.05
Orotate19.8 (2.74)Pyrimidine metabolism155.01
Phosphoethanolamine13.6 (1.14)Phospholipid metabolism140.05
Glycerol 2-phosphate11.0 (1.15)Glycerolipid metabolism171.05
N1,N12-diacetylspermine7.84 (1.73)Polyamine metabolism287.21
N-acetylserine7.71 (0.36)Glycine, serine, and threonine metabolism146.01
Glycerol7.42 (0.98)Glycerolipid metabolism91.01
Glycerophosphoglycerol5.29 (0.23)Glycerolipid metabolism245.01
Guanine4.92 (0.89)Purine metabolism152.11
Putrescine4.87 (0.83)Polyamine metabolism89.15
2′-deoxyuridine4.80 (0.66)Pyrimidine metabolism227.15
Nicotinate ribonucleoside4.73 (0.67)Nicotinate and nicotinamide metabolism256.15
1-stearoyl-GPG (18:0)4.69 (0.81)Lysophospholipid511.35
Mannose-6-phosphate4.29 (1.26)Fructose, mannose, and galactose metabolism259.05
15 metabolites showing the greatest decrease
N6-carboxymethyllysine0.37 (0.04)Advanced glycation end-product205.14
S-lactoylglutathione0.37 (0.03)Glutathione metabolism378.14
Pyrraline0.36 (0.06)Food component/plant255.14
Dihydroxyacetone phosphate0.36 (0.03)Glycolysis, gluconeogenesis, and pyruvate metabolism169.04
3-methylcytidine0.31 (0.04)Pyrimidine metabolism258.14
1-linoleoyl-GPC (18:2)0.30 (0.04)Lysophospholipid520.34
2-phosphoglycerate0.29 (0.08)Glycolysis, gluconeogenesis, and pyruvate metabolism185.04
Ribitol0.27 (0.03)Pentose metabolism151.14
Gamma-glutamylglutamate0.27 (0.03)Gamma-glutamyl amino acid277.14
Isovalerylglycine0.26 (0.05)Leucine, isoleucine, and valine metabolism158.14
1-stearoyl-GPC (18:0)0.25 (0.04)Lysophospholipid524.44
1-oleoyl-GPC (18:1)0.22 (0.04)Lysophospholipid522.44
1-palmitoyl-GPC (16:0)0.20 (0.03)Lysophospholipid496.34
Sedoheptulose-7-phosphate0.10 (0.01)Pentose phosphate pathway289.04
Fructose-6-phosphate0.03 (0.00)Glycolysis, gluconeogenesis, and pyruvate metabolism259.04
  1. amu atomic mass unit, GPC glycerophosphocholine, GPG glycerophosphoglycerol, GPI glycerophosphoinositol, GPS glycerophosphoserine, iRBC infected erythrocyte, SD standard deviation, uRBC uninfected erythrocyte
  2. aFold-change (FCIDC) values based on a comparison of the average abundance of a metabolite during the IDC in the iRBC culture relative to that in the uRBC culture
  3. bValues provided by METABOLON©
  4. cCluster in Fig. 2e containing the metabolite