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Table 2 Fold changes in metabolite levels between infected and uninfected erythrocyte cultures

From: Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

Metabolite

FCIDC (SD)a

Pathway

Mass (amu)b

Clusterc

15 metabolites showing the greatest increase

Pipecolate

63.9 (10.1)

Lysine degradation

130.1

5

Nicotinic acid mononucleotide

33.6 (3.19)

Nicotinate and nicotinamide metabolism

336.0

5

Orotate

19.8 (2.74)

Pyrimidine metabolism

155.0

1

Phosphoethanolamine

13.6 (1.14)

Phospholipid metabolism

140.0

5

Glycerol 2-phosphate

11.0 (1.15)

Glycerolipid metabolism

171.0

5

N1,N12-diacetylspermine

7.84 (1.73)

Polyamine metabolism

287.2

1

N-acetylserine

7.71 (0.36)

Glycine, serine, and threonine metabolism

146.0

1

Glycerol

7.42 (0.98)

Glycerolipid metabolism

91.0

1

Glycerophosphoglycerol

5.29 (0.23)

Glycerolipid metabolism

245.0

1

Guanine

4.92 (0.89)

Purine metabolism

152.1

1

Putrescine

4.87 (0.83)

Polyamine metabolism

89.1

5

2′-deoxyuridine

4.80 (0.66)

Pyrimidine metabolism

227.1

5

Nicotinate ribonucleoside

4.73 (0.67)

Nicotinate and nicotinamide metabolism

256.1

5

1-stearoyl-GPG (18:0)

4.69 (0.81)

Lysophospholipid

511.3

5

Mannose-6-phosphate

4.29 (1.26)

Fructose, mannose, and galactose metabolism

259.0

5

15 metabolites showing the greatest decrease

N6-carboxymethyllysine

0.37 (0.04)

Advanced glycation end-product

205.1

4

S-lactoylglutathione

0.37 (0.03)

Glutathione metabolism

378.1

4

Pyrraline

0.36 (0.06)

Food component/plant

255.1

4

Dihydroxyacetone phosphate

0.36 (0.03)

Glycolysis, gluconeogenesis, and pyruvate metabolism

169.0

4

3-methylcytidine

0.31 (0.04)

Pyrimidine metabolism

258.1

4

1-linoleoyl-GPC (18:2)

0.30 (0.04)

Lysophospholipid

520.3

4

2-phosphoglycerate

0.29 (0.08)

Glycolysis, gluconeogenesis, and pyruvate metabolism

185.0

4

Ribitol

0.27 (0.03)

Pentose metabolism

151.1

4

Gamma-glutamylglutamate

0.27 (0.03)

Gamma-glutamyl amino acid

277.1

4

Isovalerylglycine

0.26 (0.05)

Leucine, isoleucine, and valine metabolism

158.1

4

1-stearoyl-GPC (18:0)

0.25 (0.04)

Lysophospholipid

524.4

4

1-oleoyl-GPC (18:1)

0.22 (0.04)

Lysophospholipid

522.4

4

1-palmitoyl-GPC (16:0)

0.20 (0.03)

Lysophospholipid

496.3

4

Sedoheptulose-7-phosphate

0.10 (0.01)

Pentose phosphate pathway

289.0

4

Fructose-6-phosphate

0.03 (0.00)

Glycolysis, gluconeogenesis, and pyruvate metabolism

259.0

4

  1. amu atomic mass unit, GPC glycerophosphocholine, GPG glycerophosphoglycerol, GPI glycerophosphoinositol, GPS glycerophosphoserine, iRBC infected erythrocyte, SD standard deviation, uRBC uninfected erythrocyte
  2. aFold-change (FCIDC) values based on a comparison of the average abundance of a metabolite during the IDC in the iRBC culture relative to that in the uRBC culture
  3. bValues provided by METABOLON©
  4. cCluster in Fig. 2e containing the metabolite