Fig. 1

Dose-dependent changes in inhibition of parasite liver burden from seven independent studies. Dose versus log₁₀ total flux achieved in mice receiving 600, 300, 100, 30, and 0 µg doses of AB311 is shown. Curves represent the dose–response relationship estimated using 4PL models for each experiment and points represent the observed flux for each mouse. Mean and 95% CI for estimated ID50s, the dose by which liver burden is reduced 50% between the upper and lower bounds of measurement, are shown for each study