Skip to main content

Table 2 Comparison of Anti-CSP mAbs in reduction in parasite liver burden

From: Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Study number

ID50

IC50

AB311 (µg/mL)

AB317 (µg/mL)

Ratio

P value

AB311 (µg/mL)

AB317 (µg/mL)

Ratio

P value

6

109 (74, 144)

74 (59, 87)

1.5

0.07

32 (21, 44)

22 (17, 28)

1.4

0.15

7

104 (80, 127)

64 (44, 83)

1.6

0.04

26 (19, 32)

21 (15, 28)

1.2

0.39

Pooled

107 (85, 128)

69 (58, 80)

1.6

< 0.01

29 (22, 35)

22 (18, 26)

1.3

0.11

  1. ID 50 and IC50 values and 95% confidence intervals (parentheses) and the fold difference (ratio) between antibodies. ID50 results are reported in µg and IC50 reported in µg/mL. All group sizes were five per dose