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Table 2 Comparison of Anti-CSP mAbs in reduction in parasite liver burden

From: Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Study numberID50IC50
AB311 (µg/mL)AB317 (µg/mL)RatioP valueAB311 (µg/mL)AB317 (µg/mL)RatioP value
6109 (74, 144)74 (59, 87)1.50.0732 (21, 44)22 (17, 28)1.40.15
7104 (80, 127)64 (44, 83)1.60.0426 (19, 32)21 (15, 28)1.20.39
Pooled107 (85, 128)69 (58, 80)1.6< 0.0129 (22, 35)22 (18, 26)1.30.11
  1. ID 50 and IC50 values and 95% confidence intervals (parentheses) and the fold difference (ratio) between antibodies. ID50 results are reported in µg and IC50 reported in µg/mL. All group sizes were five per dose