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Table 5 Comparison of IC50 estimations for AB311 and AB317 in probability of infection

From: Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Study

AB311 (μg/mL)

AB317 (μg/mL)

Ratio

P value

1

87 (54, 121)

47 (27, 67)

1.9

0.06

2

78 (58, 98)

42 (30, 53)

1.9

< 0.01

3

61 (33, 90)

60 (30, 89)

1.0

0.48

Pooled

74 (57, 92)

49 (37, 61)

1.5

0.02

  1. Using 2PL analysis, with serum antibody concentration as the input reduction of 50% of infection probability was estimated in three studies and a pooled group with data from all three studies using a 2PL model. IC50 are depicted with 95% CI in parenthesis
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Malaria Journal

ISSN: 1475-2875

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