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Table 5 Comparison of IC50 estimations for AB311 and AB317 in probability of infection

From: Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

StudyAB311 (μg/mL)AB317 (μg/mL)RatioP value
187 (54, 121)47 (27, 67)1.90.06
278 (58, 98)42 (30, 53)1.9< 0.01
361 (33, 90)60 (30, 89)1.00.48
Pooled74 (57, 92)49 (37, 61)1.50.02
  1. Using 2PL analysis, with serum antibody concentration as the input reduction of 50% of infection probability was estimated in three studies and a pooled group with data from all three studies using a 2PL model. IC50 are depicted with 95% CI in parenthesis