Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Table 6 Single dose comparison results between AB311 and AB317

Dose	Study	Proportion infected		Barnard P value	Log Rank P value
Dose	Study	AB311	AB317	Barnard P value	Log Rank P value
100 µg	Study 1	1.00	0.86	0.260	0.002
	Study 2	1.00	1.00	1.000	0.096
	Study 3	1.00	1.00	1.000	0.043
	Pooled	1.00	0.95	0.263	< 0.001
300 µg	Study 1	0.71	0.29	0.090	0.033
	Study 2	0.57	0.00	0.012	0.035
	Study 3	0.57	0.43	0.395	0.153
	Pooled	0.62	0.24	0.007	0.002

The proportion infected at each dose were compared using the Barnard test and survival times (Fig. 4) were compared using the log-rank test using the exact conditional distribution

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