Test system | Test item | Washes | Cone test (N = 80) | WHO tunnel test (N = 100) | Pass/fail WHO efficacy criteria (2013) | ||
---|---|---|---|---|---|---|---|
%KD60 [95% CI] | %24-h mortality [95% CI] | %Feeding inhibition [95% CI] | %24-h mortality [95% CI] | ||||
Susceptible Anopheles gambiae s.s (Ifakara strain) | Olyset® | 0 | 100 | 03.75 [01.47–06.03] | – | – | Pass |
1 | 100 | 31.64 [29.40–33.89] | – | – | Pass | ||
3 | 96.25 [95.06–97.44] | 01.25 [00.06–02.44] | – | – | Pass | ||
5 | 93.75 [89.24–98.26] | 0 | – | – | Pass | ||
10 | 93.75 [92.56–94.94] | 02.50 [01.12–03.88] | – | – | Pass | ||
15 | 83.75 [79.68–87.82] | 01.25 [00.06–02.44] | 100 | 90.91 | Pass | ||
20 | 75.00 [69.85–80.15] | 03.75 [01.47–06.03] | 96.00 | 51.52 | Pass | ||
DawaPlus® 2.0 | 0 | 100 | 92.50 [90.12–94.88] | – | – | Pass | |
1 | 100 | 100 | – | – | Pass | ||
3 | 100 | 98.75 [97.56–99.94] | – | – | Pass | ||
5 | 100 | 97.50 [96.12–98.88] | – | – | Pass | ||
10 | 100 | 96.25 [92.68–99.80] | – | – | Pass | ||
15 | 100 | 93.75 [87.79–99.71] | – | – | Pass | ||
20 | 100 | 100 | – | – | Pass | ||
Resistant Anopheles arabiensis (Kingani strain) | Olyset® | 0 | 38.75 [34.68–42.82] | 0 | – | – | – |
1 | 25.00 [19.85–30.15] | 01.25 [00.06–2.44] | – | – | – | ||
3 | 23.75 [19.68–27.82] | 03.75 [01.47–6.03] | 96.00 | 09.18 | Pass | ||
5 | 51.25 [47.18–55.32] | 03.75 [02.56–4.94] | 87.00 | 12.24 | Fail | ||
10 | 36.25 [33.25–39.25] | 01.25 [00.06–2.44] | 87.00 | 14.29 | Fail | ||
15 | 53.75 [40.79–66.71] | 0 | 92.00 | 19.39 | Pass | ||
20 | 58.75 [57.56–59.94] | 0 | 88.00 | 22.45 | Fail | ||
DawaPlus® 2.0 | 0 | 50.00 [44.85–55.15] | 10.00 [05.64–14.35] | – | – | – | |
1 | 63.75 [61.47–66.03] | 11.25 [06.74–15.76] | – | – | – | ||
3 | 67.50 [63.37–71.63] | 16.25 [15.06–17.44] | 90.00 | 61.62 | Pass | ||
5 | 91.25 [87.68–94.82] | 36.25 [31.34–41.16] | 94.00 | 56.57 | Pass | ||
10 | 100 | 23.75 [19.68–27.82] | 94.00 | 78.79 | Pass | ||
15 | 97.50 [96.12–98.88] | 05.00 [01.63–08.37] | 68.00 | 51.52 | Pass | ||
20 | 93.75 [89.24–98.26] | 12.50 [09.42–15.58] | 93.00 | 41.41 | Pass |