Table 3 I-ACT results against susceptible Anopheles gambiae s.s and resistant An. arabiensis
Test system | Test items | %24-h mortalitya [95% CI] | Odds of dying [95% CI] | p-value | % feeding inhibition [95% CI] | Odds of feeding [95% CI] | p-value |
|---|---|---|---|---|---|---|---|
Susceptible Anopheles gambiae s.s. (Ifakara strain) | LS Olyset® unwashed New Olyset® unwashed | 99.30 [98.25–100.0] 96.28 [93.64–98.93] | 1.00 0.17 [0.04–0.79] | 0.024 | 94.00 [92.76–99.11] 97.27 [94.84–99.69] | 1.00 0.54 [0.05–5.80] | 0.610 |
LS Olyset® washed New Olyset® washed | 85.73 [76.58–94.86] 85.44 [74.29–96.59] | 1.00 1.09 [0.61–1.93] | 0.775 | 91.40 [88.66–94.14] 92.29 [88.73–95.86] | 1.00 0.84 [0.35–1.99] | 0.693 | |
Old DawaPlus® 2.0 unwashed New DawaPlus® 2.0 unwashed | 99.66 [98.88–100.0] 99.65 [98.88–100.0] | – | – | 96.12 [94.40–97.83] 89.37 [82.90–95.84] | 1.00 2.14 [0.62–7.47] | 0.231 | |
Old DawaPlus® 2.0 washed New DawaPlus® 2.0 washed | 100 96.94 [95.56–98.32] | – | – | 95.62 [92.81–98.42] 83.81 [78.98–88.64] | 1.00 4.37 [2.67–7.15] | 0.0001 | |
Resistant Anopheles arabiensis (Kingani strain) | Old Olyset® unwashed New Olyset® unwashed | 63.40 [47.83–78.97] 50.31 [33.42–67.19] | 1.00 0.49 [0.33–0.72] | 0.0001 | 92.10 [88.24–95.95] 95.16 [91.07–99.26] | 1.00 0.37 [0.08–1.76] | 0.213 |
Old Olyset® washed New Olyset® washed | 33.34 [17.91–48.77] 37.85 [20.11–55.59] | 1.00 1.18 [0.81–1.72] | 0.401 | 84.25 [79.51–88.99] 86.88 [80.34–93.43] | 1.00 0.67 [0.29–1.51] | 0.329 | |
Old DawaPlus® 2.0 unwashed New DawaPlus® 2.0 unwashed | 71.30 [56.28–86.32] 68.91 [50.64–87.19] | 1.00 0.82 [0.53–1.3] | 0.364 | 91.57 [88.72–94.41] 81.78 [75.49–88.07] | 1.00 2.55 [1.61–4.06] | 0.0001 | |
Old DawaPlus® 2.0 washed New DawaPlus® 2.0 washed | 48.73 [34.18–63.28] 45.74 [27.90–63.57] | 1.00 0.86 [0.60–1.22] | 0.393 | 83.28 [76.48–90.08] 59.87 [49.89–69.85] | 1.00 4.07 [2.60–6.36] | 0.0001 |