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Table 1 Overview of randomized clinical trials included in the systematic review

From: Systematic review of statistical methods for safety data in malaria chemoprevention in pregnancy trials

1st Author, year (reference)Study siteDSMBHypothesisMaskingComparator drug(s)Experimental drug(s)
Luntamo 2010 [39]MalawiYesSuperioritySingle-blindedTwo-dose IPTp-SPAZ-SP
Monthly SP
Valea 2010 [40]Burkina FasoNoSuperiorityNot statedTwo-dose IPTpThree IPTp-SP
Diakite 2010 [41]MaliYesSuperiorityOpen-labelTwo-dose IPTpThree IPTp-SP
Ndyomugyenyi 2011 [42]UgandaYesSuperiorityDouble blindedIPTp-SPITN + placeboIPTp-SP + ITN
Wini 2013 [43]Solomon IslandsYesSuperiorityOpen-labelIPTp-SP-CQ prophylaxis
Denoeud-Ndam 2014 [44]BeninYesNoninferiorityOpen-labelIPTp-MQ,(IPTp-MQ) and CTX (low CD4)CTX(low CD4)CTX(high CD4)
González 2014 [45]Benin, Gabon, Mozambique, and TanzaniaYesSuperiorityOpen-labelIPTp-SPTwo-dose MQ
Split-dose MQ
González 2014 [46]Kenya, Mozambique, and TanzaniaYesSuperiority CTX and PlaceboCTX and (IPTp-MQ)
Klement 2014 [47]TogoYesNoninferiorityOpen-labelIPTp-SPCTX
Manyando 2014 [48]ZambiaYesNoninferiorityOpen-labelIPTp-SPCTX
Desai 2015 [49]KenyaNoSuperiorityOpen-labelIPTp-SPIPTp-DP
IST-DP
Unger 2015 [50]Papua New GuineaYesSuperioritySingle blindedIPTp-AZCQone-dose SP-CQ
Kakuru 2016 [51]UgandaNoSuperiorityDouble blindedIPTp-SP,IPTp-DP
IPTp–IPTp-DP
Kimani 2016 [52]Benin, Kenya, Malawi, Tanzania, and UgandaYesSuperiorityOpen-labelIPTp-SPIPTp-AZCQ
Natureeba 2017 [53]UgandaNoSuperiorityDouble blindedTMP-SMXTMP-SMX + DP
Divala 2018 [54]MalawiYesSuperiorityOpen-labelIPTp-SPIPTp-CQ
CQ prophylaxis
Akinyotu 2018 [55]NigeriaNoSuperioritySingle-blindIPTp-SPIPTp-MQ
Kajubi 2019 [56]UgandaNoSuperiorityDouble-blindIPTpSPIPTpDP
  1. AL: Artemether-lumefantrine; CTX: Cotrimoxazle; Q: Quinine; AS: Artesunate; AQ: Amodiaquine; MQ: Mefloquine; CQ: Chloroquine; DP: Dihydroartemisinin-piperaquine; TMP-SMX: Trimethoprim-sulfamethoxazole; PQ: Piperaquine