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Fig. 3 | Malaria Journal

Fig. 3

From: Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies

Fig. 3

Antibody reactivity and EPCR-binding inhibition in Luminex. a Anti-HB3var03 CIDRα1.4 IgG levels in serum. b EPCR-binding inhibition of pooled, purified IgG in  %. c Serum-IgG levels to 42 CIDRα1 protein variants not including the immunogen variant HB3var03 measured in 3–5 mice. d EPCR-binding inhibition of 33 EPCR-binding CIDRα1 protein variants (also excluding HB3var03). All for mice immunized with catCIDRα1.4 or CIDRα1.4cat on VLP or as soluble antigen in Freund’s incomplete adjuvant. Box plots showing median reactivity with 25th and 75th percentiles, upper and lower adjacent values and outliers. *Indicate statistically significant difference, P = 0.03 and P = 0.05 for catCIDRα1.4 and CIDRα1.4cat, respectively using Wilcoxon rank-sum test

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Malaria Journal

ISSN: 1475-2875

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