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Table 3 Effect of independent factors on the release of ART from FDC ART/LUM tablets

From: Development of a dissolution method for lumefantrine and artemether in immediate release fixed dose artemether/lumefantrine tablets

Time (min)

Factor settings

Mean (%) release

A1

A2

A3

30

100

3.3

1.5

87.65a

100

1.3

1.5

80.88ab

100

3.3

0.5

77.70b

100

1.3

0.5

64.58c

50

1.3

1.5

46.92d

50

3.3

1.5

45.87d

50

1.3

0.5

44.72de

50

3.3

0.5

35.86e

LSD (0.05)

9.3

CV

3.88

p-value

0.01

 

A2

A3

Mean (%) release

60

3.3

1.5

73.00a

3.3

0.5

72.63a

1.3

1.5

71.71a

1.3

0.5

57.15b

LSD (0.05)

6.36

CV

4.1

p-value

0.001

A1

A2

Mean (%) release

100

3.3

92.52a

100

1.3

76.41b

50

3.3

53.12c

50

1.3

52.45c

LSD (0.05)

6.36

CV

4.1

p-value

0.001

 

A2

A3

Mean (%) release

90

3.3

1.5

82.59a

1.3

1.5

77.83b

3.3

0.5

76.56b

1.3

0.5

60.73c

LSD (0.05)

4.14

CV

2.46

p-value

0.000

A1

A2

Mean (%) release

100

3.3

94.17a

100

1.3

79.15b

50

3.3

64.98c

50

1.3

59.42d

LSD (0.05)

6.36

CV

4.1

p-value

0.000

 

A2

A3

Mean (%) release

120

3.3

1.5

93.03a

3.3

0.5

83.40b

1.3

1.5

81.26b

1.3

0.5

65.69c

LSD (0.05)

4.47

CV

2.44

p-value

0.01

A1

A3

Mean (%) release

100

1.5

94.01a

100

0.5

87.05b

50

1.5

80.27c

50

0.5

62.03d

LSD (0.05)

4.47

CV

2.44

p-value

0.000

  1. Means with the same letters are not significantly different from each other