Table 6 Dissolution (n = 6) of ART and LUM from FDC ART/LUM tablets
Time (min) | pH | Agitation speed (rpm) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ART | LUM | ART | LUM | |||||||||
1.4 | 1.6 | 1.8 | 1.4 | 1.6 | 1.8 | 98 | 100 | 102 | 98 | 100 | 102 | |
30 | 73.2 | 75.7 | 80.0 | 77.1 | 79.6 | 78.7 | 77.4 | 79.3 | 76.9 | 73.0 | 78.1 | 72.6 |
60 | 80.9 | 84.6 | 85.9 | 88.2 | 85.8 | 84.8 | 82.2 | 85.7 | 84.7 | 83.2 | 84.6 | 85.9 |
90 | 89.0 | 91.3 | 92.9 | 91.1 | 95.5 | 96.1 | 88.8 | 90.4 | 87.6 | 92.9 | 96.0 | 96.4 |
120 | 94.0 | 94.7 | 96.5 | 95.2 | 98.1 | 99.0 | 89.5 | 93.3 | 91.7 | 98.9 | 99.1 | 98.9 |
Average at 60 min | 83.81 ± 2.62 | 86.24 ± 1.75 | 84.20 ± 1.79 | 84.59 ± 1.34 | ||||||||
%RSD | 3.13 | 2.04 | 0.02 | 0.01 | ||||||||
p > 0.05 | ||||||||||||