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Table 1 List of serum proteins internalized in malaria-infected red blood cells (iRBCs)

From: The malaria parasite Plasmodium falciparum in red blood cells selectively takes up serum proteins that affect host pathogenicity

#

Identified proteins

Seruma

Lysateb

Uptake ratioc

1

Vitamin K-dependent protein Sd

2.38

62.12

26.10

2

Prothrombind

13.08

135.46

10.36

3

Vitronectind

4.76

18.98

3.99

4

Alpha-2-HS-glycoproteind

8.32

28.47

3.42

5

C4b-binding protein alpha chaind

28.54

50.04

1.75

6

Complement C5d

32.1

37.1

1.16

7

Hornerin

2.38

2.59

1.09

8

Apolipoprotein L1

3.57

3.45

0.97

9

Complement component C9

4.76

3.45

0.72

10

Complement C1q subcomponent subunit C

3.57

1.73

0.48

11

Antithrombin-III

35.67

15.53

0.44

12

Insulin-like growth factor-binding protein complex acid labile subunit

5.95

2.59

0.44

13

Clusterin

4.76

1.73

0.36

14

Protein AMBP

7.13

2.59

0.36

15

Heparin cofactor 2

19.03

6.9

0.36

16

Plasma protease C1 inhibitor

17.84

6.04

0.34

17

Fibronectin

73.72

22.43

0.30

18

Apolipoprotein(a)

5.95

1.73

0.29

19

Inter-alpha-trypsin inhibitor heavy chain H1

47.56

13.8

0.29

20

Plasminogen

28.54

7.77

0.27

21

Alpha-1-antitrypsin

93.94

23.3

0.25

22

Immunoglobulin lambda-like polypeptide 5

21.4

5.18

0.24

23

Complement factor B

32.1

7.77

0.24

24

Ig mu chain C region

36.86

8.63

0.23

25

Alpha-1-antichymotrypsin

28.54

6.04

0.21

26

Inter-alpha-trypsin inhibitor heavy chain H2

48.75

9.49

0.19

27

Inter-alpha-trypsin inhibitor heavy chain H4

35.67

6.9

0.19

28

Complement C3

330.56

52.63

0.16

29

Ceruloplasmin

49.94

7.77

0.16

30

Ig alpha-1 chain C region

59.45

7.77

0.13

31

Complement component C6

7.13

0.86

0.12

32

Alpha-2-macroglobulind

222.36

26.75

0.12

33

Complement C4-B

136.74

16.39

0.12

34

Complement C4-A

137.93

16.39

0.12

35

Ig gamma-1 chain C regiond

156.96

15.53

0.10

36

Histidine-rich glycoprotein

17.84

1.73

0.10

37

Apolipoprotein E

17.84

1.73

0.10

38

Apolipoprotein A–Id

54.7

5.18

0.09

39

Serum paraoxonase/arylesterase 1

19.03

1.73

0.09

40

Ig gamma-3 chain C regiond

107.02

8.63

0.08

41

Ig gamma-2 chain C regiond

114.15

8.63

0.08

42

Complement C1s subcomponent

11.89

0.86

0.07

43

Serum albumind

1850.19

128.56

0.07

44

Apolipoprotein B-100d

363.85

15.53

0.04

45

Alpha-1B-glycoprotein

21.4

0.86

0.04

46

Gelsolin

22.59

0.86

0.04

47

Kininogen-1

30.92

0.86

0.03

48

Haptoglobin

60.64

0.86

0.01

49

Serotransferrin

259.22

0

0

50

Ig gamma-4 chain C regiond

80.86

0

0

  1. aTotal spectral count (TSC) of serum protein
  2. bTSC of isolated parasite lysate protein
  3. cUptake ratio = TSC of isolated parasite lysate protein/TSC of serum protein
  4. dUptake of protein was confirmed by western blotting in Fig. 1a
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Malaria Journal

ISSN: 1475-2875

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