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Table 2 Summary of alkaloids

From: The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Compound subclass Isolated metabolites Plasmodial strain (activities) Plant species (Family), Taxon IDb Part of the plant studied Place of harvest (Locality, Country) Author, references
Aporphines 1 to 2 K1 (8.24 and 2.90 μM, respectively) Annickia kummeriae (Annonaceae), NCBI:txid225831 Leaves Amani Nature Reserve, Tanzania Malebo et al. [58]
Furoquinolines 3a to 6 FcB1 (from 162.47 to 298.16 μM) Teclea nobilis (Rutaceae), NCBI:txid1220089 Fruits and leaves Kamwenge district, Uganda Lacroix et al. [59]
7 Dd2 (IC50 = 35 μM) Melicope madagascariensis (Rutaceae), NCBI:txid1487113 Stem bark Antsasaka forest of Moramanga, Madagascar Rasamison et al. [60]
Indoles 8a to 13 and 15 3D7 (from 0.41 to 110.58 μM) Strychnos icaja (Loganiaceae), NCBI:txid1040889 Stem bark Bertoua, Cameroon Tchinda et al. [61]
14 FCA20 (0.617 μM) Strychnos icaja (Loganiaceae), NCBI:txid1040889 Roots Kasongo-Lunda, DR Congo Beaufay et al. [62], Frédérich et al. [63]
W2 (0.085 μM)
Indolosesquiterpenes 16a and 17a NF54 (7.6 μM and 29.1 μM, respectively) Polyalthia oliveri (Annonaceae), NCBI:txid105756 Stem bark Mount Kala, Cameroon Kouam et al. [64]
Naphthylisoquinolines 18a and 19a NF54 (0.043 and 0.055 μM, respectively) Ancistrocladus sp. (Ancistrocladaceae), NCBI:txid 63071 Leaves Mbandaka, DR Congo Lombe et al. [65]
20a, 21`a, 22a and 23 to 25 NF54 (from 0.090 to 6.54 μM) Ancistrocladus ileboensis (Ancistrocladaceae), NCBI:txid1367080 Leaves and root bark Bambange, DR Congo Li et al. [66]
K1 (0.228 μM for compound 19)
26a, 27a, 28a and 29a NF54 (from 0.84 to 22.2 μM) Ancistrocladus ealaensis (Ancistrocladaceae), NCBI:txid714098 Twigs and leaves Mbandaka, DR Congo Tshitenge et al. [67]
K1 (from 1.4 to 8.2 μM)
Protoberberines 30 to 33 K1 (from 0.22 to 0.71 μM) Annickia kummeriae (Annonaceae), NCBI:txid225831 Leaves Amani Nature Reserve, Tanzania Malebo et al. [58]
34 K1 (IC50 = 318.66 μM) Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806 Stem Tikrom, near Kumasi, Ghana Gbedema et al. [68]
Pyridinones 35 K1 (IC50 = 81.28 μM) Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806 Stem Tikrom, near Kumasi, Ghana Gbedema et al. [68]
Others 36 K1 (IC50 = 32.12 μM) Canthium multiflorum (Rubiaceae), NCBI:txid58501 Aerial part Obala, along River Sanaga, Cameroon Kouam et al. [69]
  1. aCompounds identified for the first time in the cited publications
  2. bIdentification number of the source species, derived from the NCBI Taxonomy database