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Table 2 Summary of alkaloids

From: The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Compound subclass

Isolated metabolites

Plasmodial strain (activities)

Plant species (Family), Taxon IDb

Part of the plant studied

Place of harvest (Locality, Country)

Author, references

Aporphines

1 to 2

K1 (8.24 and 2.90 μM, respectively)

Annickia kummeriae (Annonaceae), NCBI:txid225831

Leaves

Amani Nature Reserve, Tanzania

Malebo et al. [58]

Furoquinolines

3a to 6

FcB1 (from 162.47 to 298.16 μM)

Teclea nobilis (Rutaceae), NCBI:txid1220089

Fruits and leaves

Kamwenge district, Uganda

Lacroix et al. [59]

7

Dd2 (IC50 = 35 μM)

Melicope madagascariensis (Rutaceae), NCBI:txid1487113

Stem bark

Antsasaka forest of Moramanga, Madagascar

Rasamison et al. [60]

Indoles

8a to 13 and 15

3D7 (from 0.41 to 110.58 μM)

Strychnos icaja (Loganiaceae), NCBI:txid1040889

Stem bark

Bertoua, Cameroon

Tchinda et al. [61]

14

FCA20 (0.617 μM)

Strychnos icaja (Loganiaceae), NCBI:txid1040889

Roots

Kasongo-Lunda, DR Congo

Beaufay et al. [62], Frédérich et al. [63]

W2 (0.085 μM)

Indolosesquiterpenes

16a and 17a

NF54 (7.6 μM and 29.1 μM, respectively)

Polyalthia oliveri (Annonaceae), NCBI:txid105756

Stem bark

Mount Kala, Cameroon

Kouam et al. [64]

Naphthylisoquinolines

18a and 19a

NF54 (0.043 and 0.055 μM, respectively)

Ancistrocladus sp. (Ancistrocladaceae), NCBI:txid 63071

Leaves

Mbandaka, DR Congo

Lombe et al. [65]

20a, 21`a, 22a and 23 to 25

NF54 (from 0.090 to 6.54 μM)

Ancistrocladus ileboensis (Ancistrocladaceae), NCBI:txid1367080

Leaves and root bark

Bambange, DR Congo

Li et al. [66]

K1 (0.228 μM for compound 19)

26a, 27a, 28a and 29a

NF54 (from 0.84 to 22.2 μM)

Ancistrocladus ealaensis (Ancistrocladaceae), NCBI:txid714098

Twigs and leaves

Mbandaka, DR Congo

Tshitenge et al. [67]

K1 (from 1.4 to 8.2 μM)

Protoberberines

30 to 33

K1 (from 0.22 to 0.71 μM)

Annickia kummeriae (Annonaceae), NCBI:txid225831

Leaves

Amani Nature Reserve, Tanzania

Malebo et al. [58]

34

K1 (IC50 = 318.66 μM)

Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806

Stem

Tikrom, near Kumasi, Ghana

Gbedema et al. [68]

Pyridinones

35

K1 (IC50 = 81.28 μM)

Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806

Stem

Tikrom, near Kumasi, Ghana

Gbedema et al. [68]

Others

36

K1 (IC50 = 32.12 μM)

Canthium multiflorum (Rubiaceae), NCBI:txid58501

Aerial part

Obala, along River Sanaga, Cameroon

Kouam et al. [69]

  1. aCompounds identified for the first time in the cited publications
  2. bIdentification number of the source species, derived from the NCBI Taxonomy database