The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Table 5 Summary of steroids

Compound subclass	Isolated metabolites	Plasmodial strain (activities)	Plant species (Family), Taxon ID^b	Part of the plant studied	Place of harvest (City, Country)	Author, references
Ergostane phytosterols	109^a, 110^a, and 111	3D7 (IC₅₀ values range from 11.2 to 22.0 µM)	Antrocaryon klaineanum (Anacardiaceae), NCBI:txid289695	Stem bark	Mount Kala, Cameroon	Douanla et al. [94]
	109^a, 110^a, and 111	W2 ( IC₅₀ values range from 11.2 to 22.0 µM)	Antrocaryon klaineanum (Anacardiaceae), NCBI:txid289695	Stem bark	Mount Kala, Cameroon	Douanla et al. [94]
	112	W2mef (IC₅₀ value = 53.45 µM)	Peperomia vulcanica (Piperaceae), NCBI:txid1719589	Whole plant	Mount Cameroon, Cameroon	Ngemenya et al. [79]
	113	W2 (IC₅₀ value = 153.79 µM)	Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806	Stem	Tikrom, near Kumasi, Ghana	Gbedema et al. [68]
	113	W2 (IC₅₀ value = 172.9 µM)	Turraea robusta (Meliaceae), NCBI:txid1899148	Stem bark	Nairobi, Kenya	Irungu et al. [95]
	113	D6 (IC₅₀ value = 68.3 µM)	Turraea robusta (Meliaceae), NCBI:txid1899148	Stem bark	Nairobi, Kenya	Irungu et al. [95]
Phytosterol glucosides	114 to 116	D6 and W2 (from weak to moderate activities)	Turraea nilotica (Meliaceae), NCBI:txid992803	Stem bark	Nairobi, Kenya	Irungu et al. [95]

^aCompounds identified for the first time in the cited publications
^bIdentification number of the source species, derived from the NCBI Taxonomy database

ISSN: 1475-2875