Table 6 Summary of diterpenoids and sesquiterpenoids
Compound subclass | Isolated metabolites | Plasmodial strain (activities) | Plant species (Family), Taxon IDb | Part of the plant studied | Place of harvest (Locality, Country) | Author, references |
|---|---|---|---|---|---|---|
Clerodane diterpenes | 117 to 119 | K1 (IC50 values range from 9.59 to 18.41 µM) | Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806 | Stem | Tikrom, near Kumasi, Ghana | Gbedema et al. [68] |
Daphnane diterpenoids | 120 | FcB1 (IC50 value = 19.02 µM) | Neoboutonia macrocalyx (Euphorbaceae), NCBI:txid316724 | Stem bark | Kibale National Park, Uganda | Namukobe et al. [96] |
121 and 122 | D6 (IC50 values = 65.14 and 6.96 µM, respectively) | Neoboutonia macrocalyx (Euphorbaceae), NCBI:txid316724 | Stem bark | Kibale National Park, Uganda | Namukobe et al. [93] | |
W2 (IC50 values = 57.82 and 4.10 µM, respectively) | ||||||
Iridoid diterpenoid | 123 | K1 (IC50 value = 171.68 µM) | Canthium multiflorum (Rubiaceae), NCBI:txid58501 | Aerial part | Obala, along River Sanaga, Cameroon | Kouam et al. [69] |
Labdane diterpenoids | 124 | Suppression of Plasmodium berghei at doses of 25, 50 and 100 mg/kg with chemosuppression values of 50.13, 65.58 and 73.16%, respectively. | Otostegia integrifolia (syn: Rydingia integrifolia, Lamiaceae), NCBI:txid483857 | Leaves | Chancho, Central Ethiopia | Endale et al. [97] |
Norcassane furanoditerpene | 125 | 3D7 (IC50 value = 2.20 μM) | Caesalpinia bonducella (Caesalpiniaceae), NCBI:txid53845 | Roots | Dar es Salaam Region, Tanzania | Nondo et al. [98] |
Dd2 (IC50 value = 4.16 μM) | ||||||
Sesquiterpenoids | 126a, 127a, 128a, 129a, and 130a | W2 (IC50 values range from 1.71 to 2.63 µM) | Salacia longipes (Celastraceae), NCBI:txid662028 | Seeds | Mount Kala, Cameroon | Mba’ning et al. [99] |
131a | NF54 (IC50 value = 15.69 μM) | Scleria striatinux (Cyperaceae), NCBI:txid1916803 | Rhizomes | Oku, Cameroon | Nyongbela et al. [100] | |
K1 (IC50 value = 13.54 μM) |