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Table 6 Summary of diterpenoids and sesquiterpenoids

From: The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Compound subclass Isolated metabolites Plasmodial strain (activities) Plant species (Family), Taxon IDb Part of the plant studied Place of harvest (Locality, Country) Author, references
Clerodane diterpenes 117 to 119 K1 (IC50 values range from 9.59 to 18.41 µM) Polyalthia longifolium var. pendula (Annonaceae), NCBI:txid235806 Stem Tikrom, near Kumasi, Ghana Gbedema et al. [68]
Daphnane diterpenoids 120 FcB1 (IC50 value = 19.02 µM) Neoboutonia macrocalyx (Euphorbaceae), NCBI:txid316724 Stem bark Kibale National Park, Uganda Namukobe et al. [96]
121 and 122 D6 (IC50 values = 65.14 and 6.96 µM, respectively) Neoboutonia macrocalyx (Euphorbaceae), NCBI:txid316724 Stem bark Kibale National Park, Uganda Namukobe et al. [93]
W2 (IC50 values = 57.82 and 4.10 µM, respectively)
Iridoid diterpenoid 123 K1 (IC50 value = 171.68 µM) Canthium multiflorum (Rubiaceae), NCBI:txid58501 Aerial part Obala, along River Sanaga, Cameroon Kouam et al. [69]
Labdane diterpenoids 124 Suppression of Plasmodium berghei at doses of 25, 50 and 100 mg/kg with chemosuppression values of 50.13, 65.58 and 73.16%, respectively. Otostegia integrifolia (syn: Rydingia integrifolia, Lamiaceae), NCBI:txid483857 Leaves Chancho, Central Ethiopia Endale et al. [97]
Norcassane furanoditerpene 125 3D7 (IC50 value = 2.20 μM) Caesalpinia bonducella (Caesalpiniaceae), NCBI:txid53845 Roots Dar es Salaam Region, Tanzania Nondo et al. [98]
Dd2 (IC50 value = 4.16 μM)
Sesquiterpenoids 126a, 127a, 128a, 129a, and 130a W2 (IC50 values range from 1.71 to 2.63 µM) Salacia longipes (Celastraceae), NCBI:txid662028 Seeds Mount Kala, Cameroon Mba’ning et al. [99]
131a NF54 (IC50 value = 15.69 μM) Scleria striatinux (Cyperaceae), NCBI:txid1916803 Rhizomes Oku, Cameroon Nyongbela et al. [100]
K1 (IC50 value = 13.54 μM)
  1. aCompounds identified for the first time in the cited publications
  2. bIdentification number of the source species, derived from the NCBI Taxonomy database