The role of complement immune response on artemisinin-based combination therapy in a population from malaria endemic region of Western Kenya

Table 2 Correlation between parasitological response to drugs and pre-existing GIA activity

Clearance kinetic ^a	Age group	n subjects	T_1/2 vs GIA^b		K vs GIA^b
Clearance kinetic ^a	Age group	n subjects	−HA^c	+ HA^c	−HA	+ HA
< 2.02	< 5 years	9	R² = − 0.698 p = 0.025^*	R² = − 0.413 p = 0.207	R² = 0.604 p = 0.05^*	R² = 0.302 p = 0.367
< 2.02	≥ 5 years	16	R² = − 0.181 p = 0.518	R² = − 0.042 p = 0.886	R² = − 0.03 p = 0.915	R² = − 0.043 p = 0.878
> 2.02	< 5 years	37	R² = 0.21 p = 0.304	R² = 0.193 p = 0.335	R² = − 0.217 p = 0.208	R² = − 0.158 p = 0.432
> 2.02	≥ 5 years	43	R² = − 0.017 p = 0.923	R² = − 0.221 p = 0.217	R² = 0.037 p = 0.837	R² = 0.266 p = 0.2

^aStratification of study participants based on Slope half-life T1/2 ¹⁷ measured in hours
^bCorrelation expressed as Pearson correlation coefficient (R²); asterisk indicates statistical significance (p ≤ 0.05)
^cGIA activity assessed in sera without (−HA) or with heat-inactivation (+HA)

ISSN: 1475-2875