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Fig. 2 | Malaria Journal

Fig. 2

From: Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

Fig. 2

Schematic of plasmepsin 2/3 gene duplication. a Gene model depicting the plasmepsin 2/3 breakpoint (dashed blue lines) observed in Cambodian isolates. Primer positions are labeled in the single copy (top) and multi-copy (bottom) isolates. b Amplification primer set BF + AR amplifies a product in an isolate with two copies (PH1387-C) and three copies (PH1265-C) of plasmepsin 2/3. No product is observed for the single copy (PH1310-C) isolate or in the DNA-negative control (−). c Control primers amplify a product in the single copy (PH1310-C) and multi-copy isolates (PH1387-C; PH1265-C). No product is observed in the DNA-negative control (−)

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Malaria Journal

ISSN: 1475-2875

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