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Fig. 2 | Malaria Journal

Fig. 2

From: The thermostability of the RTS,S/AS01 malaria vaccine can be increased by co-lyophilizing RTS,S and AS01

Fig. 2

Evaluation of the antigen and adjuvant in freshly reconstituted CL-vac. a, b Analysis of two batches of CL-vac and two control RTS,S batches by SEC-HPLC and determination of RTS,S antigenicity as measured by ELISA. c, d The average liposome size (ZAD) and liposome size homogeneity (PDI) were determined for control AS01 and CL-vac (two batches). The dashed lines indicate the acceptance criteria set for the release of AS01 in liquid form (lower and upper limits for ZAD; upper limit for PDI). e The level of hydrolyzed QS-21 was measured in control AS01 and two batches of CL-vac. The dashed line indicates the upper threshold set for the release of AS01 in liquid form. f Determination of the proportion of MPL congeners (tetra, penta and hexa) in control AS01 and two batches of CL-vac. The dashed lines indicate the respective accepted ranges of congener proportions for the release of the adjuvant in liquid form

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