Groups | Compounds | Dose (mg/kg) | Average % parasitaemia ± SD (Day 7) | % Suppression of parasitaemia (Day 7) | CLogP | P-value |
---|---|---|---|---|---|---|
Oil | – | – | 5.33 ± 2.17 | – | – | – |
DMSO | – | – | 5.46 ± 0.94 | – | – | – |
CQ | – | 25 | 0.21 ± 0.22 | 96.10 | 5.06 | – |
1 | 1a | 125 | 2.49 ± 1.67 | 53.75 | ||
1b | 62 | 2.55 ± 1.30 | 52.72 | 3.93 | > 0.05 | |
1c | 31 | 4.79 ± 1.22 | 11.11 | |||
2 | 2a | 125 | 1.56 ± 1.53 | 71.07 | ||
2b | 62 | 2.31 ± 1.27 | 57.17 | 4.46 | > 0.05 | |
2c | 31 | 2.53 ± 0.95 | 53.05 | |||
3 | 3a | 125 | 2.50 ± 1.08 | 53.61 | ||
3b | 62 | 2.72 ± 2.10 | 49.56 | 2.50 | > 0.05 | |
3c | 31 | 1.11 ± 0.81 | 79.42 | |||
4 | 4a | 125 | 2.69 ± 1.02 | 50.08 | ||
4b | 62 | 3.44 ± 1.95 | 36.25 | 3.03 | > 0.05 | |
4c | 31 | 3.84 ± 0.58 | 28.87 |