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Table 3 Evaluation of average % parasitaemia and  % suppression of parasitaemia in Rane’s test

From: In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives

Groups Compounds Dose (mg/kg) Average  % parasitaemia ± SD (Day 7) % Suppression of parasitaemia (Day 7) CLogP P-value
Oil 5.33 ± 2.17
DMSO 5.46 ± 0.94
CQ 25 0.21 ± 0.22 96.10 5.06
1 1a 125 2.49 ± 1.67 53.75   
1b 62 2.55 ± 1.30 52.72 3.93 > 0.05
1c 31 4.79 ± 1.22 11.11   
2 2a 125 1.56 ± 1.53 71.07   
2b 62 2.31 ± 1.27 57.17 4.46 > 0.05
2c 31 2.53 ± 0.95 53.05   
3 3a 125 2.50 ± 1.08 53.61   
3b 62 2.72 ± 2.10 49.56 2.50 > 0.05
3c 31 1.11 ± 0.81 79.42   
4 4a 125 2.69 ± 1.02 50.08   
4b 62 3.44 ± 1.95 36.25 3.03 > 0.05
4c 31 3.84 ± 0.58 28.87   
  1. The in vivo activities were evaluated against Plasmodium berghei
  2. Italic values indicate the best compounds based on Rane’s test
  3. SD standard deviation