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Table 3 Evaluation of average % parasitaemia and  % suppression of parasitaemia in Rane’s test

From: In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives

Groups

Compounds

Dose (mg/kg)

Average  % parasitaemia ± SD (Day 7)

% Suppression of parasitaemia (Day 7)

CLogP

P-value

Oil

5.33 ± 2.17

DMSO

5.46 ± 0.94

CQ

25

0.21 ± 0.22

96.10

5.06

1

1a

125

2.49 ± 1.67

53.75

  

1b

62

2.55 ± 1.30

52.72

3.93

> 0.05

1c

31

4.79 ± 1.22

11.11

  

2

2a

125

1.56 ± 1.53

71.07

  

2b

62

2.31 ± 1.27

57.17

4.46

> 0.05

2c

31

2.53 ± 0.95

53.05

  

3

3a

125

2.50 ± 1.08

53.61

  

3b

62

2.72 ± 2.10

49.56

2.50

> 0.05

3c

31

1.11 ± 0.81

79.42

  

4

4a

125

2.69 ± 1.02

50.08

  

4b

62

3.44 ± 1.95

36.25

3.03

> 0.05

4c

31

3.84 ± 0.58

28.87

  
  1. The in vivo activities were evaluated against Plasmodium berghei
  2. Italic values indicate the best compounds based on Rane’s test
  3. SD standard deviation