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Table 1 In vitro anti-malarial activities and the cytotoxicities of Coptis rhizome and three chlorinated compounds representing its major bioactive components

From: Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds

Name IC50 CC50 SI
3D7 Dd2 3D7 Dd2
Crud drug extract (µg/mL)
 Coptis rhizome 1.9 ± 0.84 4.85 ± 2.33 > 500 > 263 > 103
Compounds (µM)
 Coptisine chloride 1.1 ± 0.05 3.1 ± 0.07 41.1 37.8 13.2
 Berberine chloride 2.6 ± 1.22 6.3 ± 0.47 8.6 3.3 1.3
 Palmatine chloride 6.0 ± 3.4 11.8 ± 1.62 > 100 > 16.7 > 8.5
  1. Values are the mean from two independent experiments performed in duplicate
  2. IC50, 50% inhibitory concentration
  3. CC50, 50% cytotoxic concentration using adult mouse brain cells
  4. SI, selectivity index