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Table 1 In vitro anti-malarial activities and the cytotoxicities of Coptis rhizome and three chlorinated compounds representing its major bioactive components

From: Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds

Name

IC50

CC50

SI

3D7

Dd2

3D7

Dd2

Crud drug extract (µg/mL)

 Coptis rhizome

1.9 ± 0.84

4.85 ± 2.33

> 500

> 263

> 103

Compounds (µM)

 Coptisine chloride

1.1 ± 0.05

3.1 ± 0.07

41.1

37.8

13.2

 Berberine chloride

2.6 ± 1.22

6.3 ± 0.47

8.6

3.3

1.3

 Palmatine chloride

6.0 ± 3.4

11.8 ± 1.62

> 100

> 16.7

> 8.5

  1. Values are the mean from two independent experiments performed in duplicate
  2. IC50, 50% inhibitory concentration
  3. CC50, 50% cytotoxic concentration using adult mouse brain cells
  4. SI, selectivity index
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Malaria Journal

ISSN: 1475-2875

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