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Table 1 Physicochemical parameters of anti-malarial drugs

From: In silico analysis for factors affecting anti-malarial penetration into red blood cells

DrugMolecular weight (g/mol)RBC ratioLogP [8]Protein binding (%)Water solubility (mg/L)
Amodiaquine355.8 [6]1.313 [7]5.179292 [9]2.83 [6]
Arteether312.41 [6]0.23 [10]3.230978.7 [11]1700 [12]
Artemether298.38 [6]0.28 [10]2.840895.4 [6]12.1 [6]
Artemisinin282.34 [6]0.49 [10]2.394982.5 [13]51.9 [14]
Artesunate384.18 [6]0.71 [10]2.602488 [15]56.2 [6]
Chloroquine319.88 [6]4.8 [16]4.810652.5 [6]0.14 [6]
Dihydroartemisinin284.35 [6]0.52 [10]2.186782 [17]3160 [18]
Doxycycline444.44 [6]0.37 [19]0.545890 [20]630 [6]
Mefloquine378.32 [6]2.8 [21]4.447998 [6]6.212 [6]
Piperaquine535.52 [6]1.5 [22]5.424197 [23]0 [24]
Primaquine259.35 [6]]1 [25]2.782775 [26]1300 [6]
Proguanil253.73 [20]4.9 [27]2.20975 [20]156 [20]
Pyrimethamine248.71 [6]0.42 [28]2.354287 [29]121 [6]
Quinine324.42 [20]1.89 [30]3.173270 [20]334 [20]
Sulfadoxine310.33 [6]0.163 [31]0.876890 [32]296 [20]
  1. RBC, red blood cell