In silico analysis for factors affecting anti-malarial penetration into red blood cells

Malaria Journal

Table 1 Physicochemical parameters of anti-malarial drugs

Drug	Molecular weight (g/mol)	RBC ratio	LogP [8]	Protein binding (%)	Water solubility (mg/L)
Amodiaquine	355.8 [6]	1.313 [7]	5.1792	92 [9]	2.83 [6]
Arteether	312.41 [6]	0.23 [10]	3.2309	78.7 [11]	1700 [12]
Artemether	298.38 [6]	0.28 [10]	2.8408	95.4 [6]	12.1 [6]
Artemisinin	282.34 [6]	0.49 [10]	2.3949	82.5 [13]	51.9 [14]
Artesunate	384.18 [6]	0.71 [10]	2.6024	88 [15]	56.2 [6]
Chloroquine	319.88 [6]	4.8 [16]	4.8106	52.5 [6]	0.14 [6]
Dihydroartemisinin	284.35 [6]	0.52 [10]	2.1867	82 [17]	3160 [18]
Doxycycline	444.44 [6]	0.37 [19]	0.5458	90 [20]	630 [6]
Mefloquine	378.32 [6]	2.8 [21]	4.4479	98 [6]	6.212 [6]
Piperaquine	535.52 [6]	1.5 [22]	5.4241	97 [23]	0 [24]
Primaquine	259.35 [6]]	1 [25]	2.7827	75 [26]	1300 [6]
Proguanil	253.73 [20]	4.9 [27]	2.209	75 [20]	156 [20]
Pyrimethamine	248.71 [6]	0.42 [28]	2.3542	87 [29]	121 [6]
Quinine	324.42 [20]	1.89 [30]	3.1732	70 [20]	334 [20]
Sulfadoxine	310.33 [6]	0.163 [31]	0.8768	90 [32]	296 [20]

ISSN: 1475-2875