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Table 3 Multiple linear regression of anti-malarial drugs and their abilities in protein binding

From: In silico analysis for factors affecting anti-malarial penetration into red blood cells

ParametersEstimateSEt-valuep-value
(Intercept)0.5990.0986.1230.000174 *
Rotatable bond− 0.0470.014− 3.3810.00811 *
Hydrogen bond acceptor0.0520.0202.5840.029 *
Aliphatic hydrocarbon− 0.1480.063− 2.3370.044 *
Aromatic hydrocarbon0.1830.0722.5170.033 *
Saturated hydrocarbon0.1850.1421.2970.227
  1. Protein binding = − 0.047 × Rotatable bond + 0.052 × Hydrogen bond acceptor–0.148 × Aliphatic hydrocarbon + 0.183 × Aromatic hydrocarbon + 0.185 × Saturated hydrocarbon + 0.599
  2. Residual standard error: 0.083 on 9 degrees of freedom
  3. Multiple R-squared: 0.692, Adjusted R-squared: 0.521
  4. F-statistic: 4.05 on 5 and 9 DF, p-value: 0.033 *
  5. * Significance value at 0.05