In silico analysis for factors affecting anti-malarial penetration into red blood cells

Malaria Journal

Table 3 Multiple linear regression of anti-malarial drugs and their abilities in protein binding

Parameters	Estimate	SE	t-value	p-value
(Intercept)	0.599	0.098	6.123	0.000174 *
Rotatable bond	− 0.047	0.014	− 3.381	0.00811 *
Hydrogen bond acceptor	0.052	0.020	2.584	0.029 *
Aliphatic hydrocarbon	− 0.148	0.063	− 2.337	0.044 *
Aromatic hydrocarbon	0.183	0.072	2.517	0.033 *
Saturated hydrocarbon	0.185	0.142	1.297	0.227

Protein binding = − 0.047 × Rotatable bond + 0.052 × Hydrogen bond acceptor–0.148 × Aliphatic hydrocarbon + 0.183 × Aromatic hydrocarbon + 0.185 × Saturated hydrocarbon + 0.599
Residual standard error: 0.083 on 9 degrees of freedom
Multiple R-squared: 0.692, Adjusted R-squared: 0.521
F-statistic: 4.05 on 5 and 9 DF, p-value: 0.033 *
* Significance value at 0.05

ISSN: 1475-2875