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Table 3 IC50 average parameters in nM for wild type (K76) and mutant (76T) P. falciparum isolates from West Africa and Central Africa for piperaquine (PPQ), quinine (QN), mefloquine (MQ), chloroquine (CQ), lumefantrine (LMF), desethylamodiaquine (DQ), pyronaridine (PND), dihydroartemisinin (DHA) and artesunate (AS)

From: Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

Drugs West Africa Central Africa
Wild type K76 (n = 76) Mutant 76T (n = 27) p value Wild type K76 (n = 82) Mutant 76T (n = 14) p value
Median Min–Max Median Min–Max Median Min–Max Median Min–Max
CQ 23.2 5.5–229.6 152.6 7.9–381 4.295E−10 28.7 5.1–474.4 113.1 14.2–325 0.0002
DQ 19.3 2.5–185.1 46.2 6.5–169.2 0.0002 20.1 4.7–85.8 32.9 16.3–152.9 0.002
QN 138.6 6.2–906.3 163.8 36.7–586 0.2 143.9 28.9–538.4 180.1 17.6–503 0.52
LMF 3.9 0.5–31.6 3.5 0.5–61.5 0.3 3.1 0.5–27.3 4.9 0.6–14.2 0.758
MQ 25.2 0.8–89.8 26.2 2.9–76.7 0.8 23.7 1.04–86.6 40.9 0.7–92.3 0.11
DHA 2.9 0.2–12.8 2.8 0.5–8.2 0.9 2.9 0.5–18.5 2.9 0.7–6.5 0.78
PND 11.8 1.1–119.3 13.3 1.9–50.2 0.7 11.3 0.2–46.6 12.3 2.7–40.8 0.99
AS 1.8 0.3–64 2.1 0.4–7.3 0.8 1.9 0.3–30.2 3.0 0.6–5.9 0.36
PPQ 20.2 1.2–78.9 28.6 7.4–544 0.08 20.6 0.7–84.6 20.9 3.4–67.1 0.82
  1. West Africa: Benin, Burkina Faso, Gambia, Ghana, Guinea, Ivory Coast, Niger, Mali, Nigeria and Togo
  2. Central Africa: Cameroon, Central African Republic, Chad, Gabon and Republic of Congo
  3. Italic p values refers to significant difference (p < 0.05)