Table 3 IC50 average parameters in nM for wild type (K76) and mutant (76T) P. falciparum isolates from West Africa and Central Africa for piperaquine (PPQ), quinine (QN), mefloquine (MQ), chloroquine (CQ), lumefantrine (LMF), desethylamodiaquine (DQ), pyronaridine (PND), dihydroartemisinin (DHA) and artesunate (AS)
Drugs | West Africa | Central Africa | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Wild type K76 (n = 76) | Mutant 76T (n = 27) | p value | Wild type K76 (n = 82) | Mutant 76T (n = 14) | p value | |||||
Median | Min–Max | Median | Min–Max | Median | Min–Max | Median | Min–Max | |||
CQ | 23.2 | 5.5–229.6 | 152.6 | 7.9–381 | 4.295E−10 | 28.7 | 5.1–474.4 | 113.1 | 14.2–325 | 0.0002 |
DQ | 19.3 | 2.5–185.1 | 46.2 | 6.5–169.2 | 0.0002 | 20.1 | 4.7–85.8 | 32.9 | 16.3–152.9 | 0.002 |
QN | 138.6 | 6.2–906.3 | 163.8 | 36.7–586 | 0.2 | 143.9 | 28.9–538.4 | 180.1 | 17.6–503 | 0.52 |
LMF | 3.9 | 0.5–31.6 | 3.5 | 0.5–61.5 | 0.3 | 3.1 | 0.5–27.3 | 4.9 | 0.6–14.2 | 0.758 |
MQ | 25.2 | 0.8–89.8 | 26.2 | 2.9–76.7 | 0.8 | 23.7 | 1.04–86.6 | 40.9 | 0.7–92.3 | 0.11 |
DHA | 2.9 | 0.2–12.8 | 2.8 | 0.5–8.2 | 0.9 | 2.9 | 0.5–18.5 | 2.9 | 0.7–6.5 | 0.78 |
PND | 11.8 | 1.1–119.3 | 13.3 | 1.9–50.2 | 0.7 | 11.3 | 0.2–46.6 | 12.3 | 2.7–40.8 | 0.99 |
AS | 1.8 | 0.3–64 | 2.1 | 0.4–7.3 | 0.8 | 1.9 | 0.3–30.2 | 3.0 | 0.6–5.9 | 0.36 |
PPQ | 20.2 | 1.2–78.9 | 28.6 | 7.4–544 | 0.08 | 20.6 | 0.7–84.6 | 20.9 | 3.4–67.1 | 0.82 |