Parasite clearance, cure rate, post-treatment prophylaxis and safety of standard 3-day versus an extended 6-day treatment of artemether–lumefantrine and a single low-dose primaquine for uncomplicated Plasmodium falciparum malaria in Bagamoyo district, Tanzania: a randomized controlled trial

Table 6 Comparing model predicted maximum serum concentration (Cmax) ng/mL for lumefantrine and desbutyl-lumefantrine by treatment arms

	Lumefantrine Cmax, ng/mL (95% CI)	p	Desbutyl-lumefantrine Cmax, ng/mL (95% CI)	p
Control arm
Recurrent parasitaemia (n = 18)	15,322.8 (12,780.8–17,864.8)	0.05	58.8 (48.7–68.9)	0.17
Non-recurrent parasitaemia (n = 17)	12,079.2 (8308.0–15,850.5)	0.05	47.8 (32.7–62.8)	0.17
Intervention
Recurrent parasitaemia (n = 13)	16,197.3 (12,505.1–19,889.5)	0.15	74.6 (59.3–89.8)	0.39
Non-recurrent parasitaemia (n = 25)	13,147.9 (9162.7–17,133.2)	0.15	72.1 (46.4–97.8)	0.39

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