Fig. 4

Mutations distribution and T cell epitopes map of pfcsp (3D7 isolate). Capital letters in black are amino acid sequences of 3D7 isolate; The red capital letters under the black ones are for mutants. Sequences with black solid line below indicated CD8+ T cell epitopes, sequences with blue dotted line above indicated CD4+ T cell epitopes. Repeat region is in gray shadow; Th2R region is in orange shadow; Th3R region is in green shadow