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Table 2 Quantification of lipid mediator (pg mg −1 muscle) in striated muscles from mice with or without different malaria infections and the associated metabolic pathways

From: The skeletal muscles of mice infected with Plasmodium berghei and Plasmodium chabaudi reveal a crosstalk between lipid mediators and gene expression

Metabolic pathways

Lipid mediator

Control

P. chabaudi

P. berghei

Arachidonic acid (AA)

6-keto-PGF1α

13.4 ± 7.9

43.9 ± 15.6

105.1 ± 77.6*

TXB2

3.4 ± 1.7

12.1 ± 12.8

26.9 ± 23.3

PGF2α

7.9 ± 2.1

38.7 ± 19.5*

38.7 ± 11.7*

PGD2

7.0 ± 0.6

53.2 ± 23.5*

34.7 ± 6.6*

PGA2

2.4 ± 0.4

10.2 ± 6.4*

5.8 ± 1.6

12-HHT

43.7 ± 5.9

145.1 ± 23.1*

182.7 ± 70**, #

AA

16,644 ± 4727.6

21,033.5 ± 9395.7

22,340.5 ± 6285.2

Linoleic acid (LA)

13-HODE

911.6 ± 183.9

5724.6 ± 5486.6

1934.3 ± 989.8

9-HODE

1159.2 ± 314.2

7427.6 ± 6820.3

2521.9 ± 1288.6

Eicosapentaenoic acid (EPA)

17,18-DiHETE

11.5 ± 1.4

8.6 ± 5.9

9.2 ± 4.1

EPA

4702.9 ± 954.4

1160 ± 292.7***

1483.4 ± 391.1***

Docosahexaenoic acid (DHA)

8-HDoHE

136.8 ± 52.9

208.3 ± 85.6

221.9 ± 49.7

DHA

73,814.6 ± 16,486.1

50,135.2 ± 9021.8*

57,149.6 ± 8011.9

α-Linolenic acid (ALA)

9-HOTrE

16.9 ± 1.2

121.4 ± 110.5

42.1 ± 13.8

Ethanolamide (EA)

AEA

21.1 ± 2.2

6.4 ± 2.9***

9.9 ± 4.4***

OEA

36.5 ± 10.5

62.9 ± 22.2

72.1 ± 25

Ratio of AA/EPA

 

3.6 ± 0.8

19.9 ± 11.9*

16.7 ± 7.7

  1. Mean ± SD, n = 5. One-way ANOVA with Tukey post hoc test (α = 0.05) was applied to compare means between multiple groups. *p < 0.05; **p < 0.01; ***p < 0.001 represent statistically significant difference between uninfected mice (Control) and P. berghei or P. chabaudi infected mice; #p < 0.05 represents statistically significant difference between P. berghei and P. chabaudi infected mice