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Fig. 4 | Malaria Journal

Fig. 4

From: Molecular characterization of Plasmodium falciparum DNA-3-methyladenine glycosylase

Fig. 4

Structural comparison of PfMAG with hAAG. a Binding of hAAG (219 residues) with double-strand DNA containing pyrrolidine (PDB 1f6O). Tyr162 intercalates into DNA duplex, flipping pyrrolidine into the active site. b Simulated 3D structure of PfMAG (502 residues) using I-TASSER server. Tyr171 intercalates into DNA strand flipping pyrrolidine into the active site. cPfMAG structure is superimposed on that of hAAG showing similarity of catalytic domain of both proteins and the extended C-terminus of the parasite protein

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