Table 2 Proportion of pfhrp2 and pfhrp3 gene deletion overall, by RDT−/microscopy+/PCR+, RDT+/microscopy+/PCR+ and by geographical location
Gene deletion | Overall proportions and stratified by RDT/microscopy results | ||||
|---|---|---|---|---|---|
Total (N = 300), Proportion n (%, 95% CI) | RDT-/micro+/PCR+ N = 165 n (%, 95% CI) | RDT+/micro+/PCR+ N = 135 n (%, 95% CI) | Prevalence ratio (RDT-/RDT+) n (95% CI) | p value | |
Any deletion | 29 (9.7, 6.6–13.6) | 24 (14.5, 9.5–20.9) | 5 (3.7, 1.2–8.4) | 3.9 (1.5–10.0) | 0.002 |
pfhrp2−/pfhrp3+ | 10 (3.3, 1.6–6.0) | 9 (5.5, 2.5–10.1) | 1 (0.7, 0.0–4.1) | 7.4 (1.0–57.4) | 0.021 |
pfhrp2 +/pfhrp3− | 9 (3.0, 1.4-5.6) | 5 (3.0, 1.0–6.9) | 4 (3.0, 0.8–7.4) | 1.02 (0.3–3.7) | 1.000 |
pfhrp2−/pfhrp3− | 10 (3.3, 1.6–6.0) | 10 (6.1, 2.9–10.9) | 0 (0.0, 0.0–2.7) | N/A | 0.004 |
pfhrp2 +/pfhrp3+ | 185 (61.7, 55.9–67.2) | 61 (37.0, 29.6–44.8) | 124 (91.9, 85.9–95.9) | 0.4 (0.3–0.5) | 0.001 |
Deletions by geographical location | ||||
|---|---|---|---|---|
Gene deletion | Eastern (N = 170), n (%, 95% CI) | Western (N = 130), n (%, 95% CI) | Prevalence ratio (Eastern/Western) n (95% CI) | p-value |
Any deletion | 25 (14.7, 9.7–20.0) | 4 (3.1, 0.8–7.7) | 4.8 (1.7–13.4) | 0.001 |
pfhrp2−/pfhrp3+ | 8 (4.7, 2.1–9.1) | 2 (1.5, 0.2–5.4) | 3.1 (0.7–14.2) | 0.125 |
pfhrp2+/pfhrp3− | 8 (4.7, 2.1–9.1) | 1 (0.8, 0.0–4.2) | 6.1 (0.8–48.3) | 0.050 |
pfhrp2−/pfhrp3− | 9 (5.3, 2.4–9.8) | 1 (0.8, 0.0–4.2) | 6.9 (0.9–53.6) | 0.032 |
pfhrp2+/pfhrp3+ | 102 (60.0, 52.2–67.4) | 83 (63.8, 55.0–72.1) | 0.9 (0.8–1.1) | 0.502 |