Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax

Malaria Journal

Table 1 Genetic polymorphism and tests of neutrality in the N-terminal and C-terminal regions of Myanmar pvcsp

Variant	Region	n	K	S	Eta	H	Hd ± SD	π ± SD	dN-dS	Tajima’s D^{P value}	Fu and Li’s D^{P value}	Fu and Li’s F^{P value}
VK210	N-terminal	143	0.098	5	6	7	0.096 ± 0.034	0.0024 ± 0.0009	0.0008	− 1.9359^c	− 3.9086^b	− 3.8409^b
VK210	C-terminal	143	0.209	10	11	11	0.186 ± 0.044	0.0035 ± 0.0009	−0.0035	− 2.2251^d	− 3.5089^b	− 3.6329^b
VK247	N-terminal	28	0.405	1	2	3	0.405 ± 0.094	0.0090 ± 0.0021	0.0117	− 0.4445^a	− 0.7114^a	− 0.7369^a
VK247	C-terminal	28	0.495	6	6	6	0.331 ± 0.114	0.0067 ± 0.0027	− 0.0150	− 1.9719^c	− 2.5946^c	− 2.8039^c

n number of analysed sequences, K average number of nucleotide differences, S number of segregating sites, Eta total number of mutations, H number of haplotypes, Hd haplotype diversity, π observed average pairwise nucleotide diversity, SD standard deviation, dN rate of non-synonymous mutations, dS rate of synonymous mutations
^aP > 0.1
^bP < 0.02
^cP < 0.05
^dP < 0.01

ISSN: 1475-2875