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Table 3 Genetic polymorphism and tests of neutrality in N-terminal and C-terminal regions of global pvcsp VK247 variants

From: Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax

Region

Country

n

K

S

Eta

H

Hd ± SD

π ± SD

dN-dS

Tajima’s DP value

Fu andLi’s Dvalue

Fu and Li’s Fvalue

N-terminal

Myanmar

28

0.405

1

2

3

0.405 ± 0.094

0.0090 ± 0.0021

0.0117

− 0.4445a

− 0.7114a

− 0.7369a

Cambodia

10

0.2

1

1

2

0.200 ± 0.154

0.0029 ± 0.0022

0.0038

− 1.1117a

− 1.2434a

− 1.3467a

Iran

11

1.309

3

3

2

0.436 ± 0.133

0.0190 ± 0.0058

− 0.0543

0.9518a

1.1271a

1.2185a

Mexico

8

0

0

0

1

0

0

0

0

0

0

Colombia

25

0

0

0

1

0

0

0

0

0

0

C-terminal

Myanmar

28

0.495

6

6

6

0.331 ± 0.114

0.0067 ± 0.0027

− 0.0150

− 1.9719c

− 2.5946c

− 2.8039c

Cambodia

10

0.400

2

2

2

0.200 ± 0.154

0.0039 ± 0.0030

− 0.0172

− 1.4009a

− 1.5866a

− 1.7190a

Iran

11

0

0

0

1

0

0

0

0

0

0

Mexico

8

0

0

0

1

0

0

0

0

0

0

Colombia

25

0.500

2

2

3

0.44 ± 0.095

0.0039 ± 0.0010

0.0017

− 0.1215a

− 0.6754a

− 0.6012a

  1. n number of analysed sequences, K average number of nucleotide differences, S number of segregating sites, Eta total number of mutations, H number of haplotypes, Hd haplotype diversity, π observed average pairwise nucleotide diversity, SD standard deviation, dN rate of non-synonymous mutations, dS rate of synonymous mutations
  2. aP > 0.1
  3. bP < 0.02
  4. cP < 0.05
  5. dP < 0.01
  6. e0.05 < P < 0.1