Fig. 4

Duplex immunization with CoPoP/MPLA liposomes does not induce mouse antibodies with improved function. Mice were immunized with 5 ng total protein (individual or duplexed) and IgG was purified form pooled sera (n = 10 mice per group). Purified IgG were fed to n = 20 mosquitoes per group at the indicated IgG in a concentrations in the standard membrane feeding assay (SMFA) and oocysts were counted 8 days later. Transmission-reducing activity corresponds to the reduction of oocyst number compared to the adjuvant alone control. The error bar indicates 95% confidence intervals