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Table 3 Diagnostic performance of the QuantiFast™ and abTES™ PCR for detecting P. knowlesi

From: Comparative evaluation of two commercial real-time PCR kits (QuantiFast™ and abTES™) for the detection of Plasmodium knowlesi and other Plasmodium species in Sabah, Malaysia

  QuantiFast™ abTES™ p-value
Sensitivity,
TP/(TP + FN);  % (95% CI)
51/52a; 98.1 (89.7, 100) 52/52; 100 (93.2, 100) 0.32
Specificity,
TN/(TN + FP);  % (95% CI)
81/82b; 98.8 (93.4, 100) 81/82c; 98.8 (93.4, 100) 1.0
ROC area, (95% CI) 0.98 (0.96, 1) 0.99 (0.98, 1) 0.46
PPV,
TP/(TP + FP);  % (95% CI)
51/52; 98.1 (89.7, 100) 52/53; 98.1 (89.9, 100) 0.56
NPV,
TN/(TN + FN);  % (95% CI)
81/82; 98.8 (93.4, 100) 81/81; 100 (95.5, 100) 0.56
  1. TP true positive, FN false negative, TN true negative, FP false positive, ROC receiver operating characteristic, PPV positive predictive value, NPV negative predictive value
  2. aA false negative result was recorded (negative for all Plasmodium species) for a P. knowlesi sample
  3. bA false positive result was recorded (a mixed P. knowlesi/P. malariae) for a P. malariae monoinfection
  4. cA false positive result was recorded (P. knowlesi) for a malaria negative control