P. knowlesi | P. vivax | p-val (Pk vs Pv) | P. falciparum | p-val (Pk vs Pf) | P. malariae | p-val (Pk vs Pm) | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
(a) QuantiFast™ | |||||||||||
PCR reference | + | − | + | − | + | − | + | − | |||
Test positive + | 51 | 1 | 25 | 0 | 21 | 0 | 9 | 1* | |||
Test negative − | 1 | 81 | 0 | 109 | 0 | 113 | 0 | 124 | |||
Sensitivity, % (95% CI) | 98.1 (89.7, 100) | 100 (86.3, 100) | 0.49 | 100 (83.9, 100) | 0.52 | 90.0 (55.5, 99.7) | 0.20 | ||||
Specificity, % (95% CI) | 98.8 (93.4, 100) | 100 (96.7, 100) | 0.25 | 100 (96.8, 100) | 0.24 | 100 (97.1, 100) | 0.22 | ||||
ROC area, (95% CI) | 0.98 (0.96, 1) | 1 (1, 1) | 0.15 | 1 (1, 1) | 0.15 | 0.95 (0.85, 1) | 0.57 | ||||
PPV, % (95% CI) | 98.1 (89.7, 100) | 100 (86.3, 100) | 0.49 | 100 (83.9, 100) | 0.52 | 100 (66.4, 100) | 0.68 | ||||
NPV, % (95% CI) | 98.8 (93.4, 100) | 100 (96.7, 100) | 0.25 | 100 (96.8, 100) | 0.24 | 99.2 (95.6, 100) | 0.77 | ||||
(b) abTES™ | |||||||||||
PCR reference | + | − | + | − | + | − | + | − | |||
Test positive + | 52 | 0 | 25 | 0 | 21 | 0 | 10 | 0 | |||
Test negative − | 1 | 81 | 0 | 109 | 0 | 113 | 0 | 124 | |||
Sensitivity, % (95% CI) | 100 (93.2, 100) | 100 (86.3, 100) | 1.0 | 100 (83.9, 100) | 1.0 | 100 (69.2, 100) | 1.0 | ||||
Specificity, % (95% CI) | 98.8 (93.4, 100) | 100 (96.7, 100) | 0.25 | 100 (96.8, 100) | 0.24 | 100 (97.1, 100) | 0.22 | ||||
ROC area, (95% CI) | 0.99 (0.98, 1) | 1 (1, 1) | 0.31 | 1 (1, 1) | 0.31 | 1 (1, 1) | 0.31 | ||||
PPV, % (95% CI) | 98.1 (89.9, 100) | 100 (86.3, 100) | 0.49 | 100 (83.9, 100) | 0.52 | 100 (69.2, 100) | 0.66 | ||||
NPV, % (95% CI) | 100 (95.5, 100) | 100 (96.7, 100) | 1.0 | 100 (96.8, 100) | 1.0 | 100 (97.1, 100) | 1.0 |