Quantification of Plasmodium knowlesi versus Plasmodium falciparum in the rhesus liver: implications for malaria vaccine studies in rhesus models

Table 1 18S rRNA quantification of liver parasite burden by lobe following intravenous inoculation of PfSPZ or PkSPZ

Animal	Group	LLL	LML	RLL	RML + C	Avg^*	Age	Sex	Weight (kg)	CRP (mg/L)
A18156	P. falciparum (1 × 10⁶)	N.D	N.D	N.D	N.D	N.D	1 year 6 months	Female	2.7	0.5
A18153	P. falciparum (1 × 10⁶)	5.31	5.73	5.35	5.88	5.57	1 year 6 months	Male	2.35	< 0.2
A18155	P. falciparum (5 × 10⁶)	N.D	N.D	5.73	4.91	5.32	1 year 6 months	Female	2.4	0.3
A18151	P. falciparum (5 × 10⁶)	6.02	6.35	6.11	6.61	6.27	1 year 6 months	Male	2.9	0.2
A18152	P. knowlesi (0.5 × 10⁶)	9.69	9.30	9.61	9.47	9.52	1 year 6 months	Male	3.15	0.2
A18154	P. knowlesi (0.5 × 10⁶)	10.09	9.53	9.82	9.45	9.72	1 year 7 months	Male	1.95	0.7

P. falciparum data reported in log₁₀ copies of 18S rRNA/g tissue as detected by the P. falciparum target. P. knowlesi data reported in log₁₀ copies of 18S rRNA/g tissue as detected by the Pan Plasmodium target
LML left medial lobe, RLL right lateral lobe, LLL left lateral lobe, RML + C right medial lobe and caudate lobe, CRP C-reactive protein, N.D not detected, F female, M male, Avg* mean of samples where Plasmodium 18S rRNA was detected

ISSN: 1475-2875