Skip to main content

Table 3 Laboratory parameters among patients, stratified by survival status

From: The clinical spectrum of severe childhood malaria in Eastern Uganda

Laboratory parameter

Overall, N (%)

Survivors (%)

Deaths (%)

P-value

Number

662

599

63

n/a

Parasitaemia

 Geometric mean (parasites/μL; 95% CI)a

58 800 (49 700–69 600)

61 110 (51 100–73 000)

41 390 (25 060–68 300)

0.078

 Hyperparasitaemiab

365/585 (62.4)

331/558 (62.6)

34/57 (59.6)

0.65

Biochemistry

 Median Lactate (mmol/L; IQR)

2.2 (1.7–4.0)

2.1 (1.7–3.6)

5.6 (2.6–9.3)

0.004

 Hyperlactataemia (≥ 5 mmol/L)

134/660 (20.3)

100/597 (16.6)

34/63 (53.9)

<0.0001

 Median blood glucose (mmol/L; IQR)

6.8 (5.5–8.4)

6.8 (5.5–8.4)

7.4 (5.2–10.0)

0.24

 Hypoglycaemia (< 2.2 mmol/L)

21/577 (3.6)

15/527 (2.8)

6/50 (12.0)

0.004

Haematology

 Median Haemoglobin (g/dL; IQR)

7.1 (4.9-10.1)

8.0 (5.1-10.1)

4.8 (3.3-9.7)

<0.0001

 Severe anaemia (Hb < 5 g/dL)

169/662 (25.5)

136 (22.7)

33 (52.3)

<0.0001

 Leucocytosisc

176/632 (27.8)

152/571(26.6)

24/61 (39.3)

0.035

 Thrombocytopaeniad

263/632 (41.6)

237/571 (41.5)

26/61 (42.6)

0.87

  1. Figures show N’s with proportions in parentheses
  2. an = 585, CI confidence interval, IQR interquartile range; P-values were estimated by χ2 tests for categorical and Student’s t-tests for continuous variables
  3. bas defined in Table 1
  4. cwhite blood cell count > 11x103 cells/mm3
  5. dplatelet count < 150x103/μL