Skip to main content

Table 3 Laboratory parameters among patients, stratified by survival status

From: The clinical spectrum of severe childhood malaria in Eastern Uganda

Laboratory parameter Overall, N (%) Survivors (%) Deaths (%) P-value
Number 662 599 63 n/a
Parasitaemia
 Geometric mean (parasites/μL; 95% CI)a 58 800 (49 700–69 600) 61 110 (51 100–73 000) 41 390 (25 060–68 300) 0.078
 Hyperparasitaemiab 365/585 (62.4) 331/558 (62.6) 34/57 (59.6) 0.65
Biochemistry
 Median Lactate (mmol/L; IQR) 2.2 (1.7–4.0) 2.1 (1.7–3.6) 5.6 (2.6–9.3) 0.004
 Hyperlactataemia (≥ 5 mmol/L) 134/660 (20.3) 100/597 (16.6) 34/63 (53.9) <0.0001
 Median blood glucose (mmol/L; IQR) 6.8 (5.5–8.4) 6.8 (5.5–8.4) 7.4 (5.2–10.0) 0.24
 Hypoglycaemia (< 2.2 mmol/L) 21/577 (3.6) 15/527 (2.8) 6/50 (12.0) 0.004
Haematology
 Median Haemoglobin (g/dL; IQR) 7.1 (4.9-10.1) 8.0 (5.1-10.1) 4.8 (3.3-9.7) <0.0001
 Severe anaemia (Hb < 5 g/dL) 169/662 (25.5) 136 (22.7) 33 (52.3) <0.0001
 Leucocytosisc 176/632 (27.8) 152/571(26.6) 24/61 (39.3) 0.035
 Thrombocytopaeniad 263/632 (41.6) 237/571 (41.5) 26/61 (42.6) 0.87
  1. Figures show N’s with proportions in parentheses
  2. an = 585, CI confidence interval, IQR interquartile range; P-values were estimated by χ2 tests for categorical and Student’s t-tests for continuous variables
  3. bas defined in Table 1
  4. cwhite blood cell count > 11x103 cells/mm3
  5. dplatelet count < 150x103/μL