From: The clinical spectrum of severe childhood malaria in Eastern Uganda
Laboratory parameter | Overall, N (%) | Survivors (%) | Deaths (%) | P-value |
---|---|---|---|---|
Number | 662 | 599 | 63 | n/a |
Parasitaemia | ||||
 Geometric mean (parasites/μL; 95% CI)a | 58 800 (49 700–69 600) | 61 110 (51 100–73 000) | 41 390 (25 060–68 300) | 0.078 |
 Hyperparasitaemiab | 365/585 (62.4) | 331/558 (62.6) | 34/57 (59.6) | 0.65 |
Biochemistry | ||||
 Median Lactate (mmol/L; IQR) | 2.2 (1.7–4.0) | 2.1 (1.7–3.6) | 5.6 (2.6–9.3) | 0.004 |
 Hyperlactataemia (≥ 5 mmol/L) | 134/660 (20.3) | 100/597 (16.6) | 34/63 (53.9) | <0.0001 |
 Median blood glucose (mmol/L; IQR) | 6.8 (5.5–8.4) | 6.8 (5.5–8.4) | 7.4 (5.2–10.0) | 0.24 |
 Hypoglycaemia (< 2.2 mmol/L) | 21/577 (3.6) | 15/527 (2.8) | 6/50 (12.0) | 0.004 |
Haematology | ||||
 Median Haemoglobin (g/dL; IQR) | 7.1 (4.9-10.1) | 8.0 (5.1-10.1) | 4.8 (3.3-9.7) | <0.0001 |
 Severe anaemia (Hb < 5 g/dL) | 169/662 (25.5) | 136 (22.7) | 33 (52.3) | <0.0001 |
 Leucocytosisc | 176/632 (27.8) | 152/571(26.6) | 24/61 (39.3) | 0.035 |
 Thrombocytopaeniad | 263/632 (41.6) | 237/571 (41.5) | 26/61 (42.6) | 0.87 |