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Table 2 Summary of pmcrt gene polymorphisms in Thailand and Myanmar

From: Genetic analysis of the orthologous crt and mdr1 genes in Plasmodium malariae from Thailand and Myanmar

Prevalence of Pmcrt polymorphism
Countries Areas N Non-synonymous mutation Synonymous mutation
Exon 2 Exon 8 Exon 2 Exon 2 Exon 2 Exon 2 Exon 9 Exon 10 Exon 12
A363C CAT > CCT H53P A2120T GAA > GAT E278D C346T F47F C353T L50L C394G T63T A403T I66I T2483C N300N T2637A L319L A3151T I375I
Thailand Kanchanaburia 6 50% (3/6) 50% (3/6) 33% (2/6) 66.66% (4/6) 0% (0/6) 50% (3/6) 1.05% (1/6) 0% (0/6) 1.05% (1/6)
Thailand Cheangmaib 1 0% (0/1) 100% (1/1) 0% (0/1) 0% (0/1) 0% (0/1) 0% (0/1) 0% (0/1) 0% (0/1) 0% (0/1)
Thailand Takc 44 70.45% (31/44) 61.36% (27/44) 31.81% (14/44) 61.36% (27/44) 0% (0/44) 47.72% (21/44) 0% (0/44) 0% (0/44) 9.09% (4/44)
Thailand Total 51 66.66% (34/51) 60.78% (31/51) 31.37% (16/51) 60.78% (31/51) 0% (0/51) 47.05% (24/51) 1.96% (1/51) 0% (0/51) 9.80% (5/51)
Myanmar Totald 44 9.09% (4/44) 25% (11/44) 4.54% (2/44) 45.45% (20/44) 9.09% (4/44) 6.81% (3/44) 2.27% (1/44) 2.27% (1/44) 2.27% (1/44)
Total in Thailand and Myanmar
N = 95
40% (38/95) 44.21% (42/95) 18.94% (18/95) 53.68% (51/95) 4.21% (4/95) 28.42% (27/95) 2.10% (2/95) 1.05% (1/95) 6.31% (6/95)
  1. Year of collection: a2002–2004, b2003, c2003–2008 and 2012–2016, d2009
  2. Accession number of reference sequence: LT594622.1