Skip to main content

Table 4 Summary of pmmdr1 gene polymorphisms in Thailand and Myanmar

From: Genetic analysis of the orthologous crt and mdr1 genes in Plasmodium malariae from Thailand and Myanmar

Prevalence of pmmdr1 polymorphism
Countries Areas N Non-synonymous mutation Synonymous mutation
NT 17 AAC > ATC N6I NT 20 TAT > TGT Y7C NT 1468 CTT > ATT L490I NT 3189 TTA > TTC L1063F NT 3743 AAC > ATC N1248I NT 3796 ACA > TCA T1266S NT 4083 AGA > AGT R1361S NT 4216 ACT > TCT T1406S NT 4378 GCC > TCC A1460S NT 4378 GCC > ACC A1460T NT 231 TCC > TCT S77S NT 1389
AGC > AGT
S463S
NT 1845
TTG > TTA
L615L
Thailand Kanchanaburia 6 0%
(0/6)
0%
(0/6)
0%
(0/6)
66.66%
(4/6)
0%
(0/6)
0%
(0/6)
1.05%
(1/6)
1.05%
(1/6)
0%
(0/6)
0%
(0/6)
0%
(0/6)
83.33%
(5/6)
33%
(2/6)
Cheangmaib 1 0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
0%
(0/1)
100%
(1/1)
100%
(1/1)
Takc 44 4.54% (2/44) 4.54% (2/44) 0% (0/44) 27.27% (12/44) 0% (0/44) 2.27% (1/44) 2.27% (1/44) 2.27% (1/44) 0% (0/44) 0% (0/44) 18.18% (8/44) 31.81%
(14/44)
25%
(11/44)
Total 51 3.92% (2/51) 3.92% (2/51) 0% (0/51) 31.37% (16/51) 0% (0/51) 1.96% (1/51) 3.92% (2/51) 3.92% (2/51) 0% (0/51) 0% (0/51) 15.68% (8/51) 39.21%
(20/51)
27.45%
(14/51)
Myanmar Totald 4 0% (0/44) 6.81% (3/44) 9.09% (4/44) 0% (0/44) 11.36% (5/44) 25% (11/44) 2.27% (1/44) 4.54% (2/44) 9.09% (4/44) 4.54% (2/44) 0% (0/44) 45.45%
(20/44)
36.36%
(16/44)
Total in Thailand and Myanmar
N = 95
2.10% (2/95) 5.26% (5/95) 4.21% (4/95) 16.84% (16/95) 5.26% (5/95) 12.63% (12/95) 3.15% (3/95) 4.21% (4/95) 4.21% (4/95) 2.10% (2/95) 8.42% (8/95) 42.10%
(40/95)
31.57%
(30/95)
  1. Year of collection: a2002–2004, b2003, c2003–2008 and 2012–2016, d2009
  2. Accession number of reference sequence: LT594631.1