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Table 2 Logistic regression analysis based on exposure to potential drug–drug interactions

From: Potential drug–drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria

Variables Univariate analysis Multivariate analysis
OR (95% CI) p-value OR (95% CI) p-value
Gender
 Female Reference   
 Male 1 (0.7–1.5) 0.9
Age (years)
 ≤ 20 Reference   Reference  
 21–40 0.6 (0.4–1) 0.05 0.6 (0.3–1.1) 0.1
 > 40 1.1 (0.6–1.9) 0.8 0.6 (0.3–1.1) 0.1
Drugs prescribed
 ≤ 4 Reference   Reference  
 5–6 4.3 (1.5–11.8) 0.005 3.9 (1.4–10.8) 0.01
 > 6 17.9 (6.9–45.9) < 0.001 14.1 (5.4–37.3) < 0.001
Hospital stay (days)
 ≤ 3 Reference   Reference  
 4–5 2.2 (1.3–3.6) 0.003 1.5 (0.8–2.6) 0.2
 > 5 3.9 (2.2–6.6) < 0.001 1.9 (1.1–3.5) 0.03
Comorbidities
 Hypertension 1.1 (0.6–1.9) 0.8
 Diabetes mellitus 2.9 (1.5–5.4) 0.001 2.2 (1–4.8) 0.04
 Urinary tract infection 1.1 (0.5–2.2) 0.9
 Hepatitis 1.6 (0.7–3.7) 0.3
 Ischemic heart disease 2.6 (0.9–7.6) 0.07 2.4 (0.7–8.5) 0.2
 Anaemia 0.5 (0.1–1.8) 0.3
 Dengue fever 1.2 (0.4–3.9) 0.7
 Meningitis 1.4 (0.4–4.7) 0.6
 Respiratory tract infection 0.5 (0.09–2.3) 0.4
 Thrombocytopenia 0.5 (0.09–2.3) 0.4
  1. CI confidence interval, OR odds ratio