Table 3 Dose regimen of the prescribed interacting drugs
Interacting pair | Dose categoriesa | Daily prescribed dose regimen | Number of patients |
|---|---|---|---|
Calcium containing products—Ceftriaxone | Low + low | 200 mg/L OD + 2 g OD ATD | 10 |
Low + low | 200 mg/L BD + 2 g OD ATD | 9 | |
Low + low | 200 mg/L BD + 1 g BD ATD | 8 | |
Low + high | 200 mg/L OD + 2 g BD ATD | 6 | |
Low + high | 200 mg/L BD + 2 g BD ATD | 5 | |
High + high | 200 mg/L TDS + 2 g BD ATD | 3 | |
High + low | 200 mg/L TDS + 2 g OD ATD | 3 | |
Low + high | 200 mg/L OD + 3 g OD ATD | 2 | |
High + low | 1 g OD +2 g OD ATD | 2 | |
Low + high | 200 mg/L BD + 3 g OD ATD | 1 | |
Low + high | 200 mg/L BD + 4 g OD ATD | 1 | |
High + high | 1 g OD +2 g BD ATD | 1 | |
Low + low | 200 mg/L OD + 1 g OD ATD | 1 | |
Isoniazid–rifampin | High + high | 300 mg OD + 600 mg OD | 6 |
Low + high | 225 mg OD + 450 mg OD | 2 | |
Low + low | 150 mg OD + 300 mg OD | 2 | |
Pyrazinamide–rifampin | High + high | 1600 mg OD + 600 mg OD | 6 |
Low + high | 1200 mg OD + 450 mg OD | 2 | |
High + low | 500 mg TDS + 300 mg OD | 2 | |
Isoniazid–acetaminophen | High + high | 300 mg OD + 500 mg TDS | 2 |
Low + high | 300 mg OD + 500 mg TDS | 2 | |
High + high | 300 mg OD + 1 g OD | 2 | |
Low + low | 150 mg OD + 300 mg OD | 1 | |
Low + high | 150 mg OD + 500 mg TDS | 1 | |
High + high | 300 mg OD + 500 mg QID | 1 | |
Prochlorperazine–quinine | High + high | 5 mg TDS + 600 mg TDS | 4 |
Low + low | 5 mg BD + 600 mg BD | 2 | |
High + high | 5 mg TDS + 450 mg TDS | 1 | |
High + low | 5 mg TDS + 300 mg TDS | 1 | |
Cefpodoxime–ranitidine | Low + low | 100 mg BD + 50 mg BD | 5 |
Low + high | 100 mg BD + 50 mg TDS | 2 | |
Metronidazole–quinine | High + high | 500 mg TDS + 600 mg TDS | 5 |
Low + low | 400 mg TDS + 600 mg BD | 1 | |
Domperidone–ranitidine | High + low | 10 mg TDS + 50 mg BD | 4 |
Low + high | 10 mg BD + 50 mg TDS | 1 | |
High + high | 10 mg TDS + 50 mg TDS | 1 | |
Dexamethasone–rifampin | High + high | 8 mg TDS + 600 mg OD | 3 |
Low + high | 8 mg BD + 600 mg OD | 1 | |
Low + low | 4 mg TDS + 450 mg OD | 1 | |
Ciprofloxacin–metronidazole | High + low | 500 mg BD + 500 mg TDS | 3 |
High + low | 400 mg BD + 500 mg TDS | 1 | |
Low + low | 250 mg BD + 500 mg TDS | 1 |