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Table 3 Sensitivity, specificity, positive and negative predictive values of RDT, routine Microscopy, MG-LAMP and expert microscopy using RT-PCR as reference

From: Evaluation of the colorimetric malachite green loop-mediated isothermal amplification (MG-LAMP) assay for the detection of malaria species at two different health facilities in a malaria endemic area of western Kenya

Method Sensitivity, % (CI) Specificity, % (CI) PV, % (CI) NPV, % (CI) K-value, % (CI)
Rota dispensary
 RDT 78.1 (67.5–86.4) 93.0 (86.8–97) 88.9 (79.3–95.1) 85.6 (78.2–91.2) 0.72 (0.59–0.86)
 MG-LAMP 82.9 (73.0–90.3) 83.5 (75.4–89.8) 78.1 (68.0–86.3) 87.3 (79.6–92.9) 0.66 (0.52–0.80)
 E-microscopy 72.0 (61–81.3) 100 (96.8–100) 100 (93.9–100) 83.3 (78–87.6) 0.75 (0.61–0.88)
Siaya Hospital
 R-microscopy 83.3 (65.3–94.4) 91.9 (78.1–98.3) 89.3 (71.8–97.7) 87.2 (72.6–95.7) 0.76 (0.52–1.00)
 MG-LAMP 93.3 (77.9–99.2) 73.0 (55.9–86.2) 73.7 (56.9–86.6) 93.1 (77.2–99.2) 0.65 (0.41–0.88)
 E-microscopy 86.7 (69.3–96.2) 91.9 (78.1–98.3) 89.7 (74.4–96.3) 89.5 (77.3–95.5) 0.79 (0.55–1.03)
  1. R-microscopy routine microscopy, E-microscopy expert microscopy, PPV positive predictive value, NPV negative predictive value, CI Confidence Interval