Table 5 Performance of uRDT and cRDT against qPCR, according to the trimester of pregnancy, gravidity, and presence of fever
uRDT | cRDT | P valuea | |
|---|---|---|---|
Sensitivity (95% CI) | |||
1st trimester | 57.0% (47.1–66.5) | 38.3% (29.1–48.2) | <10−3 |
3rd trimester | 64.9% (47.5–79.8) | 54.1% (36.9–70.5) | 0.05 |
Delivery (peripheral blood) | 83.3% (58.6–96.4) | 61.1% (35.7–82.7) | 0.05 |
Delivery (placental blood) | 40.0% (12.2–73.8) | 40.0% (12.2–73.8) | – |
Primi and Secundigravidae | 57.4% (42.2–71.7) | 44.7% (30.2–59.9) | 0.01 |
Multigravidae (3+) | 61.6% (52.5–70.2) | 44.0% (35.1–53.2) | <10−3 |
Asymptomatic | 60.8% (52.3–68.9) | 43.4% (35.1–51.9) | <10−3 |
Symptomatic* | 66.7% (41.0–86.7) | 50.0% (26.0–74.0) | 0.08 |
Specificity (95% CI) | |||
1st trimester | 91.5% (86.9–94.9) | 95.7% (92.1–98.0) | 0.003 |
3rd trimester | 95.7% (92.0–98.0) | 97.1% (93.8–99.0) | 0.08 |
Delivery (peripheral blood) | 96.4% (92.2–98.7) | 97.6% (94.0–99.3) | 0.16 |
Delivery (placental blood) | 91.3% (86.3–94.9) | 92.4% (87.6–95.8) | 0.41 |
Primi and Secundigravidae | 93.5% (88.5–96.9) | 96.1% (91.8–98.6) | 0.04 |
Multigravidae (3+) | 93.7% (91.4–95.5) | 95.6% (93.7–97.1) | 0.003 |
Asymptomatic | 94.6% (92.3–96.4) | 97.1% (95.3–98.4) | <10−3 |
Symptomaticb | 92.2% (82.7–97.4) | 93.7% (84.8–98.3) | 0.32 |