An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Table 5 Plasma pharmacokinetic parameters of AZ

Parameter	Overall (n = 11)	Infected (n = 6)	Protected (n = 5)	p
K_el (h⁻¹)	0.018 ± 0.0012	0.0183 ± 0.0167	0.02 ± 0.018	0.9
t_1/2 (h)	39.36 ± 2.1	38.065 ± 2.88	40.92 ± 3.27	0.53
T_max (h)	1.73 ± 0.14	1.67 ± 0.21	1.8 ± 0.2	0.52
C_max (ng/ml)	2155.64 ± 250.26	1682.28 ± 283.404	2723.66 ± 275.85	0.027
AUC_0–96 (ng h/ml)	14,784.64 ± 1783.88	11,316.74 ± 1244.89	18,946.12 ± 2690.78	0.044
AUC_0–∞ (ng h/ml)	17,122.03 ± 2229.41	12,951.47 ± 1474.19	22,126.71 ± 3549.22	0.059

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