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Table 6 Plasma pharmacokinetic parameters of CQ

From: An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Parameter

Overall (n = 11)

Infected (n = 6)

Protected (n = 5)

p

Kel (h−1)

0.012 ± 0.0012

0.012 ± 0.0017

0.01 ± 0.012

0.9

t1/2 (h)

65.46 ± 7.48

73.23 ± 12.78

56.14 ± 4.78

0.25

Tmax (h)

3.36 ± 0.79

3.8 ± 1.33

2.8 ± 0.8

0.52

Cmax (ng/mL)

94.18 ± 13.95

82.05 ± 14.52

108.74 ± 25.65

0.4

AUC0–96 (ng h/mL)

3102.62 ± 241

2760.58 ± 261.9

3513.072 ± 373.27

0.18

AUC0–∞ (ng h/mL)

4716.5 ± 388.97

4402.66 ± 531.85

5093.11 ± 585.51

0.41

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Malaria Journal

ISSN: 1475-2875

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