An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Table 7 Plasma pharmacokinetic parameters of CQm

Parameter	Overall (n = 11)	Infected (n = 6)	Protected (n = 5)	p
K_el (h⁻¹)	0.012 ± 0.0008	0.013 ± 0.00035	0.01 ± 0.0012	0.13
t_1/2 (h)	64.55 ± 7.67	53.41 ± 1.49	77.92 ± 15.44	0.19
T_max (h)	10.55 ± 2.67	10.67 ± 4.25	10.4 ± 3.49	0.96
C_max (ng/mL)	50.25 ± 6.73	38.92 ± 5.41	63.84 ± 10.96	0.088
AUC_0–96 (ng h/mL)	2582.67 ± 342.62	2821.26 ± 286.52	3394.23 ± 530.82	0.046
AUC_0–∞ (ng h/mL)	4373.63 ± 767.66	2769.64 ± 345.17	6236.48 ± 1235.93	0.049

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