Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

Malaria Journal

Table 10 Summary of relative organ weights (g) (FNDR-20123)–females

Groups and dose (mg/kg)	Fasting body weight (g)	Brain	Heart	Liver	Kidney	Thymus	Spleen	Lungs	Uterus
G1 F 0	145.81	1.17	0.41	4.89	1.07	0.27	0.69	0.99	0.23
G1 F 0	21.82	0.12	0.05	0.17	0.19	0.04	0.27	0.23	0.09
G2 F 50	149.51	1.25	0.44	5.03	1.04	0.18	0.47	0.95	0.24
G2 F 50	5.23	0.26	0.13	1.27	0.23	0.06	0.19	0.34	0.08
G3 F 100	143.57	1.22	0.41	4.55	1.01	0.12*	0.38	0.80	0.15
G3 F 100	15.63	0.17	0.04	0.43	0.12	0.06	0.29	0.13	0.04
G4 F 150	134.25	1.28	0.42	4.74	1.03	0.16*	0.38	0.96	0.21
G4 F 150	21.07	0.23	0.02	0.45	0.20	0.05	0.16	0.43	0.09

ISSN: 1475-2875