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Table 10 Summary of relative organ weights (g) (FNDR-20123)–females

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

Groups and dose (mg/kg) Fasting body weight (g) Brain Heart Liver Kidney Thymus Spleen Lungs Uterus
G1 F 0 145.81 1.17 0.41 4.89 1.07 0.27 0.69 0.99 0.23
21.82 0.12 0.05 0.17 0.19 0.04 0.27 0.23 0.09
G2 F 50 149.51 1.25 0.44 5.03 1.04 0.18 0.47 0.95 0.24
5.23 0.26 0.13 1.27 0.23 0.06 0.19 0.34 0.08
G3 F 100 143.57 1.22 0.41 4.55 1.01 0.12* 0.38 0.80 0.15
15.63 0.17 0.04 0.43 0.12 0.06 0.29 0.13 0.04
G4 F 150 134.25 1.28 0.42 4.74 1.03 0.16* 0.38 0.96 0.21
21.07 0.23 0.02 0.45 0.20 0.05 0.16 0.43 0.09
  1. G5-toxicokinetic group
  2. Values are in Mean ± SD; G1 vs G2, G3 & G4 (*p < 0.05)