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Table 3 Isoform selectivity of FNDR-20123 tested against recombinant human HDAC isoforms

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

Compound IC50 (nM)a
HeLa nuclear extract HDAC1 HDAC2 HDAC3 HDAC6 HDAC8
Vorinostat 78 83 78 32 128 1612
FNDR-20123 3 25 29 2 11 282
  1. aSingle experiment assays