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Table 3 Isoform selectivity of FNDR-20123 tested against recombinant human HDAC isoforms

From: Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria

Compound

IC50 (nM)a

HeLa nuclear extract

HDAC1

HDAC2

HDAC3

HDAC6

HDAC8

Vorinostat

78

83

78

32

128

1612

FNDR-20123

3

25

29

2

11

282

  1. aSingle experiment assays
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Malaria Journal

ISSN: 1475-2875

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