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Table 1 Diversity estimates of Pfrhs based on sequence variants in parasite isolates

From: Population genetic and biophysical evidences reveal that purifying selection shapes the genetic landscape of Plasmodium falciparum RH ligands in Chhattisgarh and West Bengal, India

Gene name Pfrh1 Pfrh2a/b Pfrh4 Pfrh5
No of samples (n) 47 43 46 83
Length sequenced (bp) 999 1092 921 1320
Polymorphic sites 4 8 6 18
Polymorphic Sites with frequency < 5% 2 7 4 14
Parsimony informative sites 4 2 2 8
No of haplotypes (H) 5 7 7 15
Haplotype diversity (Hd ± SD) 0.660 ± 0.052 0.532 ± 0.074 0.527 ± 0.071 0.594 ± 0.061
Average number of pairwise differences (k) 0.809 0.802 0.995 1.234
Raggedness index 0.182 0.108 0.482 0.055
Recombination event 0 0 0 2
Nucleotide diversity (π ± SD) 0.0008 ± 0.0001 0.0007 ± 0.0002 0.0011 ± 0.0002 0.0002 ± 0.0002
Watterson’s θ ± SD 0.0009 ± 0.0004 0.0017 ± 0.0006 0.0015 ± 0.00061 0.0027 ± 0.0006
Tajima’s D −0.246 −1.592 −0.702 −1.922a
Fu & Li’s Da 1.011 −2.837* −2.204 −2.915*
Fu & Li’s Fa 0.731 −2.866* −1.912 −3.042*
Average number of non-synonymous sites, dN (SE) 0.0007 ± 0.00002 0.0009 ± 0.000041 0.0006 ± 0.00002 0.001 ± 0.00002
Average number of synonymous sites, dS (SE) 0.0011 ± 0.00006 0 0.003 ± 0.0001 0.0002 ± 0.00001
dN/dS 0.7 0.2 5.8
  1. aindicates p < 0.05